Proceedings of the 2024 5th International Conference on Education, Knowledge and Information Management (ICEKIM 2024）

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Application of Bioinformatics in Drug Activity Detection

Authors
Liyun Zhao1, Jianyou Shi1, *
1Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China
*Corresponding author. Email: shijianyoude@126.com
Corresponding Author
Jianyou Shi
Available Online 31 August 2024.
DOI
10.2991/978-94-6463-502-7_124How to use a DOI?
Keywords
Bioinformatics; RNA sequencing; Neuroinflammation
Abstract

Bioinformatics (BI) uses computer technology as the research means and tool, and has gradually become an interdisciplinary field between biology, statistics, mathematics, computer science and even engineering. Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are involved in the regulation of neuroinflammation and thus exert neuroprotective effects. Phosphodiesterases (PDEs) are the only key enzymes that can catalyze the hydrolysis of cAMP and cGMP in vivo. Bioinformatics analysis is a crucial part of the ribonucleic acid (RNA). Therefore, this study, RNA sequencing technology was used to analyze the mechanism of the combination of rolipram (PDE4-specific inhibitor) and tadalafil (PDE5-specific inhibitor) by increasing the content of cAMP and cGMP, thereby inhibiting the secretion of inflammatory factors and upregulating the expression of neuroprotection-related factors, and playing a role in regulating neuroinflammation and neuroprotection.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 2024 5th International Conference on Education, Knowledge and Information Management (ICEKIM 2024）
Series
Atlantis Highlights in Computer Sciences
Publication Date
31 August 2024
ISBN
978-94-6463-502-7
ISSN
2589-4900
DOI
10.2991/978-94-6463-502-7_124How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Liyun Zhao
AU  - Jianyou Shi
PY  - 2024
DA  - 2024/08/31
TI  - Application of Bioinformatics in Drug Activity Detection
BT  - Proceedings of the 2024 5th International Conference on Education, Knowledge and Information Management (ICEKIM 2024）
PB  - Atlantis Press
SP  - 1154
EP  - 1160
SN  - 2589-4900
UR  - https://doi.org/10.2991/978-94-6463-502-7_124
DO  - 10.2991/978-94-6463-502-7_124
ID  - Zhao2024
ER  -