Subacute Toxicity of Water Fraction of Africa Leaves (Vernonia amygdalina Del.) on Blood Parameters in Male White Mice
- DOI
- 10.2991/ahsr.k.211105.040How to use a DOI?
- Keywords
- African leaves; Vernonia amygdalina Del.; water fraction; subacute toxicity; blood parameters
- Abstract
African leaves (Vernonia amygdalina Del.) is one of the plants used as traditional medicine. Although natural, traditional medicinal ingredients are not necessarily safe for use in humans. In this study, a subacute toxicity test of Afrian leaves water fraction was carried out on male white mice. This study aims to determine the effect of dosage variations and duration of administration of water fraction of African leaves (Vernonia amygdalina Del.) on blood parameters. Parameters observed were erythrocytes, leukocytes, haemoglobin and hematocrit. The experimental animals used were 36 male white mice which were divided into four groups. The first group as a negative control was given 0.5% Na CMC suspension, while three more groups were given test preparations at a dose of 10 mg/kg BW, 20 mg/kg BW and 40 mg/kg BW orally once a day for 7, 14 and 21 days. Blood parameter tests were carried out on days 8, 15 and 22. Data were analyzed by two-way Analysis of Variance (ANOVA). The results showed that variations in dosage (10 mg/kg BW, 20 mg/kg BW and 40 mg/kg BW) and duration of administration (7, 14 and 21 days) of the African leaves water fraction did not affect on blood parameters (p>0.05).
- Copyright
- © 2021 The Authors. Published by Atlantis Press International B.V.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - Dian Ayu Juwita AU - Helmi Arifin AU - Muhammad Yasin Abdullah AU - Dita Permatasari PY - 2021 DA - 2021/11/17 TI - Subacute Toxicity of Water Fraction of Africa Leaves (Vernonia amygdalina Del.) on Blood Parameters in Male White Mice BT - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021) PB - Atlantis Press SP - 277 EP - 281 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.211105.040 DO - 10.2991/ahsr.k.211105.040 ID - Juwita2021 ER -