Anti-hepatocarcinoma Effects of Resveratrol Loaded Solid Nanodispersion by a New Material Nano Silica
- DOI
- 10.2991/icaset-16.2016.59How to use a DOI?
- Keywords
- Nano silica, Solid nanodispersion, Resveratrol, Cytotoxicity, Antitumor activity, HepG2 cells
- Abstract
Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Resveratrol (Res), a major symbol ingredient in red grapes and peanuts, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Res-solid nanodispersion (Res-SND) composed of Res, poloxamer 188 and nano silica was prepared by high pressure homogenization and sieving methods. The in vitro anti-hepatocarcinoma effects of Res-SND relative to efficacy of bulk Res were evaluated. The particle size and zeta potential of Res- SND were 198.6 nm and 14.2mV, respectively. MTT assay showed that Res-SND effectively inhibited the proliferation of HepG2 cells, and the corresponding IC50 values of Res-NS and bulk Res were 2.23 and 7.13 æg/ml. These results suggest that the delivery of Res-SND is a promising approach for treating tumors.
- Copyright
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Xiang-ping Meng AU - Yi-fei Wang AU - Zhi-ping Wang PY - 2016/05 DA - 2016/05 TI - Anti-hepatocarcinoma Effects of Resveratrol Loaded Solid Nanodispersion by a New Material Nano Silica BT - Proceedings of the 2016 6th International Conference on Applied Science, Engineering and Technology PB - Atlantis Press SP - 297 EP - 302 SN - 2352-5401 UR - https://doi.org/10.2991/icaset-16.2016.59 DO - 10.2991/icaset-16.2016.59 ID - Meng2016/05 ER -