Maximum Effective Dose of Shallot Peel in Preventing Cigarette Smoke-Induced Lung Oxidative Stress

DOI

10.2991/978-94-6463-451-8_22How to use a DOI?

Keywords

shallot peel; cigarette smoke; oxidative stress; lung malondialdehyde

Abstract

Cigarette smoke is a source of free radicals and a trigger for the production of free radicals in the body and has been proven to cause oxidative stress, especially in the lungs. Continuous oxidative stress, causes an inflammatory process and lung tissue damage, the pathophysiology of chronic obstructive pulmonary disease (COPD), lung fibrosis and pulmonary cancer. Shallot peel, with a high flavonoid antioxidant content, can potentially prevent cigarette smoke-induced lung oxidative stress. This study was designed to determine the maximum effective dose of shallot peel infusion form (SPI) in preventing lung oxidative stress induced by cigarette smoke. The type of experimental laboratory was a posttest-only control group design. Rats were exposed to 2 cigarettes/day and divided into a cigarette smoke group administered aquabidest (SPI 0 mg/kgBW) and 5 SPI groups administered SPI doses of 125 mg/kgBW, 250 mg/kgBW, 500 mg/kgBW, 1,000 mg/kgBW and 2,000 mg/kgBW in 28 days treatment. Oxidative stress was measured in lung tissue using the ELISA method. Based on the regression analysis quadratic model, it was found that the maximum effective dose of SPI to prevent lung oxidative stress was 1046 mg/kgBW. It can be concluded that SPI with amounts more than 1,046 mg/kgBW is no longer effective in preventing pulmonary oxidative stress induced by cigarette smoke.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Dina Helianti
AU  - Rosita Dewi
AU  - Ayu Munawaroh
AU  - Sheilla Rachmania
PY  - 2024
DA  - 2024/07/14
TI  - Maximum Effective Dose of Shallot Peel in Preventing Cigarette Smoke-Induced Lung Oxidative Stress
BT  - Proceedings of the 8th International Conference of Food, Agriculture and Natural Resource & the Second International Conference of Sustainable Industrial Agriculture (IC-FANRES-IC-SIA 2023)
PB  - Atlantis Press
SP  - 247
EP  - 254
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-451-8_22
DO  - 10.2991/978-94-6463-451-8_22
ID  - Helianti2024
ER  -