Preparation of a Thermo-sensitive Poly(lysine ester-co-adipic acid) with Excellent Biocompatibility

DOI

10.2991/i3csee-16.2016.70How to use a DOI?

Keywords

biocompatibility; thermo-sensitive polymer; lysine acid; molecular design

Abstract

Good biocompatibility or no cytotoxicity is the most important characteristic for thermo-sensitive polymeric material because of its potential applications in the biomedical field. In this paper, a new poly (lysine ester-co-adipic acid) (PLA) with both thermo-sensitivity and good biocompatibility was designed and successfully prepared. UV measurements indicated that PLA showed a reversible phase transition at 17.3-31.7 (the lower critical solution temperature, LCST). LCST of PLA was affected by its molecular weight, structure and concentration. Moreover, the viability of HeLa cells after 24 h incubation in PLA solution was in the range of 98%-110%, suggesting good biocompatibility of PLA. In summary, the new thermo-sensitive PLA with no cytotoxicity could be utilized as a promising biomaterial in the biomedical field.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhihui Fan
AU  - Ting Jiang
AU  - Chang Zheng
AU  - Akoda Komlan Elom
AU  - Jihua Song
PY  - 2016/04
DA  - 2016/04
TI  - Preparation of a Thermo-sensitive Poly(lysine ester-co-adipic acid) with Excellent Biocompatibility
BT  - Proceedings of the 2016 International Conference on Civil, Structure and Environmental Engineering
PB  - Atlantis Press
SP  - 363
EP  - 366
SN  - 2352-5401
UR  - https://doi.org/10.2991/i3csee-16.2016.70
DO  - 10.2991/i3csee-16.2016.70
ID  - Fan2016/04
ER  -