Synthesis and Properties of Thermo-sensitive Poly(N-propionyl-L-aspartic acid-co-1,3-propylene glycol)

DOI

10.2991/i3csee-16.2016.71How to use a DOI?

Keywords

Thermo-sensitive Polymer, Upper Critical Solution Temperature(UCST), L-aspartic acid, Cell Toxicity

Abstract

In this paper, a novel poly(N-propionyl-L-aspartic acid-co-1,3-propylene glycol) (PPAP) was successfully synthesized with L-aspartic acid and 1,3-propylene glycol. The chemical structure of poly(N-propionyl-L-aspartic acid-co-1,3-propylene glycol) was characterized by FTIR and 1H NMR spectrum. The UV measurements indicated that PPAP showed a reversible phase transition and its UCST was tunable via changing the ratio of methanol(ethanol) and water. The viability of HeLa cells was found to be higher 80% after 24, 48 and 72 h incubation in the different concentrations (0.01, 0.1, 1.0, 10, and 100 g/mL) of PPAP. In summery, the experimental results showed that the synthesized polymer had excellent thermo-sensitivity and biocompatibility.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Jihua Song
AU  - Meng Wang
AU  - Akoda Komlan Elom
AU  - Chang Zheng
AU  - Zhihui Fan
PY  - 2016/04
DA  - 2016/04
TI  - Synthesis and Properties of Thermo-sensitive Poly(N-propionyl-L-aspartic acid-co-1,3-propylene glycol)
BT  - Proceedings of the 2016 International Conference on Civil, Structure and Environmental Engineering
PB  - Atlantis Press
SP  - 367
EP  - 370
SN  - 2352-5401
UR  - https://doi.org/10.2991/i3csee-16.2016.71
DO  - 10.2991/i3csee-16.2016.71
ID  - Song2016/04
ER  -