Synthesis and Characterization of a Thermo-sensitive Poly(N-propionyl-aspartic acid-co-dimethyl tartrate) with no cytotoxicity
- DOI
- 10.2991/i3csee-16.2016.69How to use a DOI?
- Keywords
- temperature-sensitive, tartaric acid, aspartic acid, cytotoxicity
- Abstract
In this paper, we used L-aspartic acid, dimethyl tartrate and propionic anhydride as raw materials to prepare a new thermo-sensitive poly(N-propionyl-L-aspartic acid-co-dimethyl tartrate) (PPADT). The chemical structures of the intermediates, monomer and polymer have been confirmed by FTIR and 1H NMR measurements. UV spectrum data showed the thermo-sensitivity of PPADT and its UCST was tunable via changing the ratio of methanol and water. It was consistent with the phenomenon of reentrant phase separation. Besides, we found that PPADT had no cytotoxicity. The survival rate of HeLa cells was more than 85% in all cases. The results suggested that poly(N-propionyl-L-aspartic acid-co-dimethyl tartrate) was a new promising material with good biocompatibility and thermo-sensitivity.
- Copyright
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Chang Zheng AU - Xueying Fan AU - Zhihui Fan AU - Jihua Song AU - Akoda Komlan Elom PY - 2016/04 DA - 2016/04 TI - Synthesis and Characterization of a Thermo-sensitive Poly(N-propionyl-aspartic acid-co-dimethyl tartrate) with no cytotoxicity BT - Proceedings of the 2016 International Conference on Civil, Structure and Environmental Engineering PB - Atlantis Press SP - 359 EP - 362 SN - 2352-5401 UR - https://doi.org/10.2991/i3csee-16.2016.69 DO - 10.2991/i3csee-16.2016.69 ID - Zheng2016/04 ER -