Some Aspects of Immune Status of Primary and Secondary Schoolchildren Living in Conditions of Technogenic Pollution of Urban Environment by Industrial Pollutants

DOI

10.2991/ahsr.k.220103.043How to use a DOI?

Keywords

immune status; primary and secondary schoolchildren; technogenic pollution; urban environment; industrial impact; regulatory systems response

Abstract

Under conditions of intensive industrial impact, the study of the specifics of the regulatory systems response will benefit effective implementation of measures aimed to preserve the health of the child population. We have studied the indicators of the immune status of schoolchildren at different levels of education under the industrial impact of the urban environment. CD-populations of lymphocytes have been studied by flow cytometry. Humoral immunity has been assessed based on the production of serum immunoglobulins by radial immunodiffusion, and specific antibodies to chemical factors – by allergosorbent testing. It has been revealed that the immune profile imbalance is especially pronounced in middle school students and is characterised by the following: a decrease in CD19⁺ and CD8⁺ lymphocytes, a reduced phagocytic activity, an increase in IgM and IgA production, a high level of sensitization for specific IgE to manganese, nickel, formaldehyde, IgG to lead, benzene, phenol, changes in the cytokine markers of interleukin-4 and interferon-gamma. These indicators reflect the state of immunological health of schoolchildren and serve as indicators of the formation of pathological trends in the context of industrial changes of the environment, which can be used for early detection of immune-mediated morbidity and development of effective preventive measures to improve the quality of life and provide a decrease in the incidence rate of children.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - K.G. Starkova
AU  - O.V. Dolgikh
PY  - 2022
DA  - 2022/01/17
TI  - Some Aspects of Immune Status of Primary and Secondary Schoolchildren Living in Conditions of Technogenic Pollution of Urban Environment by Industrial Pollutants
BT  - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
PB  - Atlantis Press
SP  - 214
EP  - 218
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220103.043
DO  - 10.2991/ahsr.k.220103.043
ID  - Starkova2022
ER  -