Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)

Synthesis of Nitrogen-containing 4-alkoxybenzaldehyde Analogues

Authors
Zhen Xiao, Sheng Tang, Xiao-Lei Wang, Peng-Wu Zheng, Shan Xu
Corresponding Author
Zhen Xiao
Available Online February 2018.
DOI
10.2991/bst-17.2018.40How to use a DOI?
Keywords
Nitrogen-containing 4-alkoxybenzaldehyde, Synthesis
Abstract

Nitrogen-containing 4-alkoxybenzaldehyde analogues as a kind of water-soluble aldehyde are important intermediates for small molecule anticancer drugs. A rapid and high yield synthetic method for nitrogen-containing 4- alkoxybenzaldehyde analogues was established in this work. The target compound was synthesized from the commercially available 4-alkoxybenzaldehyde through two steps nucleophilic substitution. The structure of the target product was confirmed by 1HNMR and MS. In addition, the synthetic method was optimized. The total yield of the two steps was high up to 99%.

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
Series
Advances in Biological Sciences Research
Publication Date
February 2018
ISBN
978-94-6252-472-9
ISSN
2468-5747
DOI
10.2991/bst-17.2018.40How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Zhen Xiao
AU  - Sheng Tang
AU  - Xiao-Lei Wang
AU  - Peng-Wu Zheng
AU  - Shan Xu
PY  - 2018/02
DA  - 2018/02
TI  - Synthesis of Nitrogen-containing 4-alkoxybenzaldehyde Analogues
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 259
EP  - 262
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.40
DO  - 10.2991/bst-17.2018.40
ID  - Xiao2018/02
ER  -