Synthesis of Nitrogen-containing 4-alkoxybenzaldehyde Analogues
Authors
Zhen Xiao, Sheng Tang, Xiao-Lei Wang, Peng-Wu Zheng, Shan Xu
Corresponding Author
Zhen Xiao
Available Online February 2018.
- DOI
- 10.2991/bst-17.2018.40How to use a DOI?
- Keywords
- Nitrogen-containing 4-alkoxybenzaldehyde, Synthesis
- Abstract
Nitrogen-containing 4-alkoxybenzaldehyde analogues as a kind of water-soluble aldehyde are important intermediates for small molecule anticancer drugs. A rapid and high yield synthetic method for nitrogen-containing 4- alkoxybenzaldehyde analogues was established in this work. The target compound was synthesized from the commercially available 4-alkoxybenzaldehyde through two steps nucleophilic substitution. The structure of the target product was confirmed by 1HNMR and MS. In addition, the synthetic method was optimized. The total yield of the two steps was high up to 99%.
- Copyright
- © 2018, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Zhen Xiao AU - Sheng Tang AU - Xiao-Lei Wang AU - Peng-Wu Zheng AU - Shan Xu PY - 2018/02 DA - 2018/02 TI - Synthesis of Nitrogen-containing 4-alkoxybenzaldehyde Analogues BT - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017) PB - Atlantis Press SP - 259 EP - 262 SN - 2468-5747 UR - https://doi.org/10.2991/bst-17.2018.40 DO - 10.2991/bst-17.2018.40 ID - Xiao2018/02 ER -