Synthesis of Tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H) -carboxylate

DOI

10.2991/bst-17.2018.41How to use a DOI?

Keywords

Tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H)-carboxylate, Synthesis

Abstract

Tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H)-carboxylate(9) is an important intermediate for small molecule anticancer drugs. A rapid and high yield synthetic method for tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H)-carboxylate was established in this work. The target compound was synthesized from the commercially available piperidin-4-ylmethanol (5) through four steps including nucleophilic substitution reaction, oxidation reaction, halogenation reaction and elimination reaction. The structure of the target product was confirmed by 1H NMR. In addition, the synthetic method was optimized. The total yield of the four steps was high up to 71.4%.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Bin-Liang Zhang
AU  - Ke-Jun Ye
AU  - Shan Xu
AU  - Tong-Sheng Xu
PY  - 2018/02
DA  - 2018/02
TI  - Synthesis of Tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H) -carboxylate
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 263
EP  - 267
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.41
DO  - 10.2991/bst-17.2018.41
ID  - Zhang2018/02
ER  -