Synthesis of Diethyl 2-(2-chloronicotinoyl)malonate

DOI

10.2991/bst-17.2018.39How to use a DOI?

Keywords

Diethyl 2-(2-chloronicotinoyl)malonate, Synthesis.

Abstract

Diethyl 2-(2-chloronicotinoyl)malonate 3 is a nitrogen-containing water-soluble carboxylic acid as an important intermediates of small molecule anticancer drugs. In this study, this paper explored a faster and celerity method to synthesize compound 3. By using 2-chloronicotinic acid as a kind of easily available compound through two steps to made the target compound. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the two steps was 83.3 %.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - He-Hua Xiong
AU  - Yong-Li Duan
AU  - Shuang Jia
AU  - Ding-Ling Shi
AU  - Zhi-Min Li
AU  - Qi-Dong Tang
PY  - 2018/02
DA  - 2018/02
TI  - Synthesis of Diethyl 2-(2-chloronicotinoyl)malonate
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 255
EP  - 258
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.39
DO  - 10.2991/bst-17.2018.39
ID  - Xiong2018/02
ER  -