(E)-3-(dimethylamino)-1-(1H-indol-3-yl)prop-2-en-1-one

DOI

10.2991/bst-17.2018.38How to use a DOI?

Keywords

(E) -3- (dimethylamino) -1- (1H-indol-3-yl) prop-2-en-1-on, Synthesis

Abstract

(E) -3- (dimethylamino) -1- (1H-indol-3-yl) prop-2-en-1-one (4) is an important intermediate in many biologically active compounds such as osimertinib. In this work, compound (4) was synthesized through three steps, using 1H-indole as starting material. The synthetic method of 4 was optimized and can be used to synthesize the derivatives of (E) -3- (dimethylamino) -1- (1H-indol-3-yl) prop-2-en-1-on. And the structure of (E)-3- (dimethylamino) -1-(1H-indol-3-yl) prop-2-en-1-one is confirmed by MS and 1HNMR spectrum.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Wen-Sheng Zou
AU  - Li-Wen Jiang
AU  - Shuang Jia
AU  - Wu-Fu Zhu
PY  - 2018/02
DA  - 2018/02
TI  - (E)-3-(dimethylamino)-1-(1H-indol-3-yl)prop-2-en-1-one
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 251
EP  - 254
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.38
DO  - 10.2991/bst-17.2018.38
ID  - Zou2018/02
ER  -