Safety Evaluation of Diethyl Citrate and Its Impact on Vascular Calcification

DOI

10.2991/bst-17.2018.10How to use a DOI?

Keywords

Anticoagulation, Vascular calcification, Acute toxicity.

Abstract

To investigate the inhibitory effects of diethyl citrate (Et2Cit) on calcification, Et2Cit was given to animals (SD rats) of the vascular calcification model. The results showed that Et2Cit is safety and non-toxic by intraperitoneal administration. Compared with control group, Et2Cit can reduce tail artery pressure and significantly reduce the calcium salt of vascular membrane elastic fibers on aortic Von Kossa staining. Et2Cit has anti-vascular calcification effect and has no side effect. This result will help to provide a new research direction and theoretical basis for the prevention and treatment of vascular calcification.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Chao-Yang Duan
AU  - Ling-Hong Huang
AU  - Da Guo
AU  - Jian-Ming Ouyang
AU  - Jin Han
AU  - Bao-Song Gui
PY  - 2018/02
DA  - 2018/02
TI  - Safety Evaluation of Diethyl Citrate and Its Impact on Vascular Calcification
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 62
EP  - 67
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.10
DO  - 10.2991/bst-17.2018.10
ID  - Duan2018/02
ER  -