Anticoagulant Properties of a New Anticoagulant Diethyl Citrate in Rabbit Model

DOI

10.2991/bst-17.2018.11How to use a DOI?

Keywords

Diethyl citrate, Anticoagulant, Hemodialysis

Abstract

A novel anticoagulant, diethyl citrate (Et2Cit) was synthesized and characterized by carbon nuclear magnetic resonance (13C NMR), mass spectrometry and UV-visible spectroscopy. There were two isomers with different chemical environments, that is, 1, 3-diethyl citrate and 1,5-diethyl citrate. Through the determination of whole blood activated clotting time (ACT), the anticoagulant effect in vitro of Et2Cit was investigated. Et2Cit can reduce ions calcium concentration in blood then to play the role of anticoagulation. Et2Cit was superior to anticoagulant Na3Cit duing to the steric hindrance of two ethyl groups in citric acid, which leading a decrease of chelated ability compared to that of Na3Cit. It can prevent hypocalcemia when Et2Cit as anticoagulation, due to the ion blood calcium concentration resumed faster than Na3Cit. Consequently Et2Cit may be a potential ideal anticoagulant.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Jin Han
AU  - Zeng-Ying Liu
AU  - Chen-Ying Rao
AU  - Jian-Ming Ouyang
AU  - Da Guo
AU  - Bao-Song Gui
PY  - 2018/02
DA  - 2018/02
TI  - Anticoagulant Properties of a New Anticoagulant Diethyl Citrate in Rabbit Model
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 68
EP  - 73
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.11
DO  - 10.2991/bst-17.2018.11
ID  - Han2018/02
ER  -