Proceedings of 5th Borobudur International Symposium on Humanities and Social Science 2023

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Anti-inflammatory Effect and Physical Stability Test of Nanoemulgel Containing Marjoram (Origanum majorana L.) Essential Oil

Authors
Ungsari Rizki Eka Purwanto1, *, Mighfar Syukur2, Tris Harni Pebriani1, Ika Puspitaningrum3
1Department of Pharmaceutical Technology, Stifar Yayasan Pharmasi Semarang, Semarang, Indonesia
2Department of Pharmaceutical Chemistry, Stifar Yayasan Pharmasi Semarang, Semarang, Indonesia
3Department of Pharmacology and Clinical Pharmacy, Stifar Yayasan Pharmasi Semarang, Semarang, Indonesia
*Corresponding author. Email: ungsaririzki@stifar.ac.id
Corresponding Author
Ungsari Rizki Eka Purwanto
Available Online 2 August 2024.
DOI
10.2991/978-2-38476-273-6_43How to use a DOI?
Keywords
Marjoram; Nanoemulgel; Antiinflamatory
Abstract

The ability of marjoram essential oil (MEO) to reduce pro-inflammatory agents, C-reactive protein (CRP), is gaining attention these days. The nanoemulgel development is needed to increase permeation of the active components. Furthermore, proving the anti-inflammatory effectiveness and stability of MEO nanoemulgel is the key to the success of the formulation. This study aimed to formulate and perform anti-inflammatory and physical stability studies on a nanoemulgel formulation containing MEO. MEO (Darjeeling CAS 8015-01-8) nanoemulgel was prepared. The edema volume formation with carrageenan is a method used for anti-inflammatory test. The stability studies used are accelerated methods and cycling tests. MEO nanoemulgel shows anti-inflammatory activity, where 2% MEO nanoemulgel produces a better anti-inflammatory effect compared to 1% MEO because it has a greater reduction in edema volume and CRP levels. Independent T-test results show that there are no significant differences in all physical preparation parameters, before and after stability test. In tests, the nanoemulgel formulation prepared in this study was found to be safe and did not cause erythema or edema when applied to the skin.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of 5th Borobudur International Symposium on Humanities and Social Science 2023
Series
Advances in Social Science, Education and Humanities Research
Publication Date
2 August 2024
ISBN
978-2-38476-273-6
ISSN
2352-5398
DOI
10.2991/978-2-38476-273-6_43How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Ungsari Rizki Eka Purwanto
AU  - Mighfar Syukur
AU  - Tris Harni Pebriani
AU  - Ika Puspitaningrum
PY  - 2024
DA  - 2024/08/02
TI  - Anti-inflammatory Effect and Physical Stability Test of Nanoemulgel Containing Marjoram (Origanum majorana L.) Essential Oil
BT  - Proceedings of 5th Borobudur International Symposium on Humanities and Social Science 2023
PB  - Atlantis Press
SP  - 384
EP  - 392
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-273-6_43
DO  - 10.2991/978-2-38476-273-6_43
ID  - Purwanto2024
ER  -