Soursop Leaf Extract Gel: A Promising Solution for Skin Bacterial Infections

DOI

10.2991/978-2-38476-273-6_120How to use a DOI?

Keywords

Soursoup Leaf; Skin Bacterial Infection; Extract Gel

Abstract

Staphylococcus aureus and Escherichia coli are mainly two commensal and pathogenic human bacteria that cause skin infections in tropical regions. Flavonoids found in Soursop leaf’s have been shown to have antibacterial effects. The aim of this research was to assess the antibacterial effectiveness of a topical gel formulation comprising an ethanol extract derived from soursop leaves against the proliferation of Escherichia coli and Staphylococcus bacteria. The soursop leaves underwent extraction through the maceration process and were subsequently formulated into a topical gel at concentrations of 1%, 5%, and 10%. Microbial testing was conducted using the well diffusion method, and the inhibitory zone was measured. A comparison was made with a negative control (no extract) and a positive control (povidone iodine) to evaluate the antibacterial efficacy. The ANOVA test was utilized to determine the statistical significance of the antibacterial activity, with a significance level set at p < 0.05. Analysis results indicate significant disparities in the antibacterial properties of the topical soursop leaf extract gel compared to the negative control. However, the antibacterial activity was less potent when compared to the positive control. To test its antibacterial effectiveness, more investigation must be done by transforming it into a Nano-shaped preparation.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Nuniek Nizmah Fajriyah
AU  - Urmatul Waznah
AU  - Eko Mugiyanto
AU  - Kusnul Khotimah
AU  - Eka Jamilatur Rosyidah
AU  - Khusnul Khotimah
AU  - Ahmad Samsudin
AU  - Nurul Hidayati
PY  - 2024
DA  - 2024/08/02
TI  - Soursop Leaf Extract Gel: A Promising Solution for Skin Bacterial Infections
BT  - Proceedings of 5th Borobudur International Symposium on Humanities and Social Science 2023
PB  - Atlantis Press
SP  - 1166
EP  - 1175
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-273-6_120
DO  - 10.2991/978-2-38476-273-6_120
ID  - Fajriyah2024
ER  -