Characteristics of Nanoparticle Caulerpa Racemosa as an Anti-Breast Cancer Agent

DOI

10.2991/978-2-38476-273-6_69How to use a DOI?

Keywords

Caulerpa Racemose Extract; Nanoparticle; Physical Characteristics; Anticancer

Abstract

Caulerpa racemosa is a marine algae rich in folic acid, thiamine, and caulerpenyne, characterized by potential anticancer, antitumor and antiproliferative properties. Despite the promising potential, the clinical application of natural ingredients often faces challenges due to low bioavailability. To address this limitation, nanotechnology provides a promising avenue for enhancing bioavailability. Therefore, this research aimed to investigate the physical characteristics, including particle size and zeta potential, of nanoencapsulated Caulerpa racemosa extract at three dosage levels of 100 mg/mL, 125 mg/mL, and 150 mg/mL. The extraction process entailed maceration for 3x24 hours, resulting in nanoparticle formed through the combination of Caulerpa racemosa extract with tween 80, a 0.3% chitosan solution in acetate buffer (pH 4), and a tripolyphosphate (TPP) solution in distilled water. Particle size analysis using Particle Size Analyzer showed that the nanoencapsulated extract had larger particle sizes in the nano range, while phytochemical screening confirmed the presence of flavonoids, alkaloids, terpenoids, and phenolics. Zeta potential and polydispersity index measurements showed that higher dosage levels led to smaller zeta potential values, although remaining below + 30 mV. Specifically, the polydispersity index was highest at a dosage level of 125 mg/mL.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Sri Haryanti
AU  - Dewi Ramonah
AU  - Mutmainah Mutmainah
PY  - 2024
DA  - 2024/08/02
TI  - Characteristics of Nanoparticle Caulerpa Racemosa as an Anti-Breast Cancer Agent
BT  - Proceedings of 5th Borobudur International Symposium on Humanities and Social Science 2023
PB  - Atlantis Press
SP  - 638
EP  - 644
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-273-6_69
DO  - 10.2991/978-2-38476-273-6_69
ID  - Haryanti2024
ER  -