Network Pharmacology of JinChaiKangBingDu Capsule Against Influenza A (H1N1) Virus Infection

DOI

10.2991/bbe-17.2017.68How to use a DOI?

Keywords

JinChaiKangBingDu capsule, Influenza A (H1N1), Network pharmacology, Systems biology.

Abstract

Pharmacological mechanisms of Chinese herbal prescription are complicate since it contains heterogeneous components. These mechanisms are hardly understood by traditional methodology in the mass. Here we use network pharmacology approaches to explore mechanisms of JinChaiKangBingDu Capsule (JCKBD) against influenza A (H1N1) virus infection at a system level. Firstly, two web-based text mining systems were used for collecting the genes/proteins that associate with H1N1 virus infection and pharmacology process of ingredients in JCKBD from literature. The 1087 genes/proteins taken part in H1N1 infection course and 140 genes/proteins influenced by ingredients in JCKBD were found, which were demonstrated by traditional experiment. Secondly, H1N1 network and JCKBD network was constructed by using data of these genes/proteins interaction from multiple protein-protein interaction databases, respectively. Then, mapping JCKBD network to H1N1 network, produced subnetworks, considered the pharmacological networks of JCKBD against H1N1 virus infection. Thirdly, analysis based on topological structure of H1N1 network revealed the proteins with high central value in these pharmacological networks of JCKBD, meaning that these proteins play important roles in the course of JCKBD against H1N1 virus infection, such as TP53, CASP3, HSP90AA1, AKT1, RELA, NFKB1, MAPK1, etc. Finally, gene ontology (GO) enrichment of the proteins in the pharmacological networks shown that significant terms involved in cellular response to stress, apoptosis and signal transduction. Therefore, it was suggested that core mechanisms of JCKBD against H1N1 virus infection at a system level should be effects on signal transduction implicating in stress response and apoptosis.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhi-de CHENG
AU  - Xiao-jing WANG
AU  - Peng DENG
AU  - Jing ZHAO
AU  - Gao CHEN
PY  - 2017/05
DA  - 2017/05
TI  - Network Pharmacology of JinChaiKangBingDu Capsule Against Influenza A (H1N1) Virus Infection
BT  - Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
PB  - Atlantis Press
SP  - 423
EP  - 430
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-17.2017.68
DO  - 10.2991/bbe-17.2017.68
ID  - CHENG2017/05
ER  -