International Journal of Networked and Distributed Computing

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Volume 4, Issue 4, October 2016, Pages 221 - 230

Frequency-specific Alterations of Functional Hub in Generalized Tonic-clonic Seizure

Authors
Zhe Zhang, Huiyan Cheng, Xuhui Chen, Chaolin Ma
Corresponding Author
Zhe Zhang
Available Online 3 October 2016.
DOI
10.2991/ijndc.2016.4.4.3How to use a DOI?
Keywords
Resting-state; GTCS; Hub; CEEMD; Frequency-specific.
Abstract

Resting-state functional magnetic resonance imaging (rs-fMRI) has shown aberrant brain functional networks at a conventional low-frequency range (0.01-0.08 Hz) in individuals with generalized tonic-clonic seizure (GTCS). However, it is unclear how functional networks hubs change across different frequency bands in GTCS patients . In this study, we applied a data-driven method called complementary ensemble empirical mode decomposition (CEEMD) to decompose the whole brain blood oxygen level-dependent (BOLD) time series into five frequency-specific bands. Then, we compared alterations of frequency-specific functional hub across five different frequency bands in 21 GTCS patients to 22 normal control (NC) subjects. CTCS patients showed aberrant functional hubs predominately at some particular frequency bands and primary in the default mode network (DMN) and the somatomotor network (SMN). Furthermore, we found these hubs located in the DMN and the SMN at some specific bands (0.015 -0.025 Hz, 0.12 - 0.25 Hz) were associated with disease severity. These findings highlight the role of frequency-specific functional hub, and may helpfully uncover abnormal neuronal activity in patients with GTCS at frequency-specific bands.

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
International Journal of Networked and Distributed Computing
Volume-Issue
4 - 4
Pages
221 - 230
Publication Date
2016/10/03
ISSN (Online)
2211-7946
ISSN (Print)
2211-7938
DOI
10.2991/ijndc.2016.4.4.3How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Zhe Zhang
AU  - Huiyan Cheng
AU  - Xuhui Chen
AU  - Chaolin Ma
PY  - 2016
DA  - 2016/10/03
TI  - Frequency-specific Alterations of Functional Hub in Generalized Tonic-clonic Seizure
JO  - International Journal of Networked and Distributed Computing
SP  - 221
EP  - 230
VL  - 4
IS  - 4
SN  - 2211-7946
UR  - https://doi.org/10.2991/ijndc.2016.4.4.3
DO  - 10.2991/ijndc.2016.4.4.3
ID  - Zhang2016
ER  -