Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 133 - 133

P3.24 SEX-SPECIFIC ASSOCIATIONS BETWEEN CAROTID DISTENSIBILITY AND PRIOR BLOOD PRESSURE CATEGORIES – RESULTS FROM THE SAPALDIA COHORT

Authors
S. Caviezel1, J. Dratva2, 3, E. Schaffner2, 3, C. Schindler2, 3, E. Zemp Stutz2, 3, N. Künzli2, 3, J.-M. Gaspoz4, T. Rochat5, N. Probst-Hensch2, 3, A. Schmidt-Trucksäss1
1Institute of Exercise and Health Sciences, Div. Sports and Exercise Medicine, University of Basel, Basel, Switzerland
2Swiss Tropical and Public Health Institute, Basel, Switzerland
3University of Basel, Basel, Switzerland
4Department of Community Medicine and Primary Care, University Hospitals of Geneva, Geneva, Switzerland
5Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva, Switzerland
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.111How to use a DOI?
Abstract

Objective: Hypertension is a major risk factor of cardiovascular events. To identify potential sex specific differences in the association of prior blood pressure (BP) to arterial stiffness, we studies the relative change of lumen diameter for a given pulse pressure (distensibility) in participants of the SAPALDIA cohort study.

Methods: In the first follow up in 2002 brachial systolic and diastolic BP were examined in 6456 participants. They were divided into five BP categories (systolicBP/diastolicBP mmHg): ‘optimal’ <120/<80; ‘normal’ 120–129/80–84; ‘high normal’ 130–139/85–89; ‘grade1 hypertension’ 140–159/90–99 and ‘grade 2+3hypertension’ ≥160/≥100. Participants were assigned to the higher category, if systolic and diastolic BP belonged to different categories. In the second follow up in 2010/2011, carotid lumen diameter of ultrasound images were analysed in 3489 subjects. BP was measured oscillometrically directly after the ultrasound examination. The analytic sample included 2576 participants with complete data. The sex-specific associations of distensibility and prior assessed BP categories were analysed using mixed regression models with fixed effects for sex, BP categories and their interactions, anthropometric parameters, classical risk factors, heart rate with random effects for study centres.

Results: Descriptive characteristics are shown in table1. The sex-specific adjusted average distensibility results are shown in figure1. A significant decline in distensibility with increasing BP category was observed compared to optimal BP category. A significant sex-specific difference was found for optimal BP category (p = 0.001).

Conclusions: Based on the assessment of carotid stiffness, BP control should be considered as an important therapeutic target both for men and women.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
133 - 133
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.111How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - S. Caviezel
AU  - J. Dratva
AU  - E. Schaffner
AU  - C. Schindler
AU  - E. Zemp Stutz
AU  - N. Künzli
AU  - J.-M. Gaspoz
AU  - T. Rochat
AU  - N. Probst-Hensch
AU  - A. Schmidt-Trucksäss
PY  - 2013
DA  - 2013/11/11
TI  - P3.24 SEX-SPECIFIC ASSOCIATIONS BETWEEN CAROTID DISTENSIBILITY AND PRIOR BLOOD PRESSURE CATEGORIES – RESULTS FROM THE SAPALDIA COHORT
JO  - Artery Research
SP  - 133
EP  - 133
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.111
DO  - 10.1016/j.artres.2013.10.111
ID  - Caviezel2013
ER  -