Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 133 - 133

P3.25 THE EFFECT OF DIASTOLIC ASYMPTOTIC PRESSURE ON THE RESERVOIR PRESSURE IN HUMAN

Authors
A. Borlotti1, S. Vermeersch2, E.R. Rietzschel2, P. Segers2, A.W. Khir1
1Brunel University, London, United Kingdom
2Ghent University, Ghent, Belgium
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.112How to use a DOI?
Abstract

Background: Arterial diastolic asymptotic pressure (P∞) is the pressure reached when the heart stops beating. Determination of the reservoir pressure (Pr) requires a value of P∞ which was previously assumed (1), calculated (2) and measured (3, 4) as 0, 35, 14, 24 mmHg respectively. The effects of varying P∞ on the determination of Pr is the primary objective of this study.

Methods: Pr was calculated from the carotid pressure of 2003 subjects of the Asklepios study (a) using a free fitting algorithm for the determination of P∞ and (b) setting P∞ to the average of the experimental values (19 mmHg).

Results: The reservoir pulse pressure (PPr) is higher using the free fitting method than setting P∞ (Fig1). PPr increases significantly with age and is higher in male than female in both cases.

Conclusions: PPr is generally higher in male than female and its absolute value is dependant on the value of P∞. Higher values of PPr suggests deterioration of the arterial buffering function with age.

Figure 1.

Changes of PPr with age and gender using the free fitting algorithm (a) and 19mmHg (b).

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1.Aguado-Sierra et al., Proceedings of the Institution of Mechanical Engineers, Part H, Journal of Engineering in Medicine, Vol. 222, No. 4, 2008, pp. 403-416.
2.Wang et al., American Journal of Physiology - Heart and Circulatory Physiology, Vol. 290, No. 1, 2006, pp. H154-H162.
3.Schipke et al., American Journal of Physiology - Heart and Circulatory Physiology, Vol. 285, No. 6, 2003, pp. H2510-H2515.
4.Jellinek et al., Journal of applied physiology, Vol. 88, No. 3, 2000, pp. 926-932.
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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
133 - 133
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.112How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A. Borlotti
AU  - S. Vermeersch
AU  - E.R. Rietzschel
AU  - P. Segers
AU  - A.W. Khir
PY  - 2013
DA  - 2013/11/11
TI  - P3.25 THE EFFECT OF DIASTOLIC ASYMPTOTIC PRESSURE ON THE RESERVOIR PRESSURE IN HUMAN
JO  - Artery Research
SP  - 133
EP  - 133
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.112
DO  - 10.1016/j.artres.2013.10.112
ID  - Borlotti2013
ER  -