Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 132 - 133

P3.23 URINARY ALBUMIN EXCRETION FROM SPOT URINE SAMPLES PREDICT ALL-CAUSE AND STROKE MORTALITY IN AFRICANS

Authors
R. Schutte1, A.E. Schutte1, H.W. Huisman1, J.M. van Rooyen1, C.M.T. Fourie1, R. Kruger1, C.M.C. Mels1, L. Malan1, N.T. Malan1, W. Smith1, M. Greeff2, A. Kruger2
1Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa
2African Unit for Transdiscipliniary Health Research, North-West University, Potchefstroom, South Africa
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.110How to use a DOI?
Abstract

Twenty-four hour urinary albumin excretion reflects general endothelial damage, relates to arterial stiffness, and predicts adverse health outcomes. Albumin determined from easily collected spot urine samples is also predictive. No prognostic evidence for albumin excretion from any means of urine collection exists for Africans. We followed health outcomes in 1061 randomly selected non-diabetic, HIV negative Africans (mean age: 51.5 years; 62.0% women). We determined the baseline urinary albumin-to-creatinine ratio from spot urine samples. Over a median follow-up of 4.52 years, 132 deaths occurred of which 47 were cardiovascular-related. The urinary albumin-to-creatinine ratio averaged 0.68 (5th to 95th percentile interval; 0.13, 4.54 mg/mmol). In multivariable-adjusted analyses, albumin excretion predicted all-cause mortality (hazard ratio, 1.26; 95% confidence interval, 1.07, 1.48; P=0.006), and a tendency existed for cardiovascular (1.26; 0.97, 1.63; P=0.087) mortality, which seemed driven by stroke (1.72; 1.17, 2.54; P=0.006) and not cardiac mortality (0.67; 0.41, 1.07; P=0.094). The predictive value remained in 528 hypertensives for both all-cause (1.38; 1.13, 1.69; P=0.001) and cardiovascular mortality (1.45; 1.07, 1.96; P=0.017), but again driven by stroke. Our findings remained significant after excluding participants with macroalbuminuria and those on anti-hypertensive treatment. In conclusion, in non-diabetic HIV-negative Africans, albumin excretion from spot urine samples predicts all-cause and stroke mortality.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
132 - 133
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.110How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - R. Schutte
AU  - A.E. Schutte
AU  - H.W. Huisman
AU  - J.M. van Rooyen
AU  - C.M.T. Fourie
AU  - R. Kruger
AU  - C.M.C. Mels
AU  - L. Malan
AU  - N.T. Malan
AU  - W. Smith
AU  - M. Greeff
AU  - A. Kruger
PY  - 2013
DA  - 2013/11/11
TI  - P3.23 URINARY ALBUMIN EXCRETION FROM SPOT URINE SAMPLES PREDICT ALL-CAUSE AND STROKE MORTALITY IN AFRICANS
JO  - Artery Research
SP  - 132
EP  - 133
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.110
DO  - 10.1016/j.artres.2013.10.110
ID  - Schutte2013
ER  -