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Volume 7, Issue 3-4, September 2013, Pages 129 - 129

P3.09 STIFFER ARTERIES IN “HEALTHY” SUBJECTS WITH COMPONENTS OF THE METABOLIC SYNDROME

Authors
O. Mac Ananey, B. Mc Loughlin, I. Abuzaid, A. Leonard, P. Gaffney, G. Boran, V. Maher
Tallaght Hospital, Dublin, Ireland
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.097How to use a DOI?
Abstract

Objectives: To compare indices of vascular stiffness and markers of adiposity and inflammation in “healthy” subjects with/without components of the metabolic syndrome (met-x).

Methods: Subjects satisfying ≥1 (≥1 Met-X;) and no criteria (0 Met-X) were recruited (IDF 2006). All were lifelong non-smokers, normotensive, normolipidaemic and normoglycaemic. Augmentation index (AIx) and pulse wave velocity (PWV) were measured using applanation tonometry (Sphygmacor & Vicorder). Fasting leptin, adiponectin, IL-6, TNFα & MCP-1 were measured. Unpaired students t-test and Fischer’s exact test was used to detect differences.

Results: Anthropometric, metabolic and haemodynamic indices of the met-x syndrome were significantly higher in the ≥1 Met-X group (p<0.0001). AIx and PWV were higher in the ≥1 Met-X group. The adipose related hormones, leptin and adiponectin were higher and lower, respectively, in the ≥1 Met-X group but the pro-inflammatory markers, IL-6, TNFα & MCP-1 were not different (Table 1).

0 Met-X criteria ≥1 Met-X criteria P
n 91 106
Age (years) 37±10 40±8 years 0.06
Body fat (%) 22.64±6.74 30.44±7.71 <0.0001
AIx (%) 12.83±13.60 19.28±13.34 <0.001
PWV (m.s−1) 6.82±0.85 7.14±1.20 <0.05
Leptin (pg.mL−1.10−2) 100.39±73.44 168.93±123.94 <0.001
Adiponectin (pg.mL−1.10−2) 77.54±41.10 53.91±31.98 <0.001
IL-6 (pg.ml−1) 1.59±0.96 2.08±3.01 0.27
TNFα (pg.ml−1) 2.98±1.10 3.29±1.50 0.21
MCP-1 (pg.ml−1) 214.26±96.85 204.51±80.15 0.55
Table 1

Body fat composition, arterial stiffness and humoral adipose/pro-inflammatory markers in subjects with/without early signs of met-x. Results are mean±SD.

Conclusion: Subjects with early met-x have stiffer arteries than those with normal metabolic function. These results suggest that premature arterial stiffening may be mediated via hormonal rather than inflammatory mechanisms.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
129 - 129
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.097How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - O. Mac Ananey
AU  - B. Mc Loughlin
AU  - I. Abuzaid
AU  - A. Leonard
AU  - P. Gaffney
AU  - G. Boran
AU  - V. Maher
PY  - 2013
DA  - 2013/11/11
TI  - P3.09 STIFFER ARTERIES IN “HEALTHY” SUBJECTS WITH COMPONENTS OF THE METABOLIC SYNDROME
JO  - Artery Research
SP  - 129
EP  - 129
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.097
DO  - 10.1016/j.artres.2013.10.097
ID  - MacAnaney2013
ER  -