P3.08 C-REACTIVE PROTEIN BUT NOT ADVANCED GLYCATION END-PRODUCTS ARE RELATED TO ALTERED GLUCOSE METABOLISM AND ARTERIAL STIFFENING IN THE MIDDLE AGED METABOLIC SYNDROME SUBJECTS: DATA FROM A CROSS SECTIONAL STUDY

L. Ryliskyte; A. Laucevicius; J. Badariene; R. Navickas; S. Solovjova

doi:10.1016/j.artres.2013.10.096

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Volume 7, Issue 3-4, September 2013, Pages 128 - 129

P3.08 C-REACTIVE PROTEIN BUT NOT ADVANCED GLYCATION END-PRODUCTS ARE RELATED TO ALTERED GLUCOSE METABOLISM AND ARTERIAL STIFFENING IN THE MIDDLE AGED METABOLIC SYNDROME SUBJECTS: DATA FROM A CROSS SECTIONAL STUDY

Authors

L. Ryliskyte¹^{, 2}, A. Laucevicius¹^{, 2}, J. Badariene¹^{, 2}, R. Navickas², S. Solovjova²

¹Vilnius University, Medical Faculty, Heart Clinic, Center of Cardiology and Angiology, Vilnius, Lithuania

²Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.096 How to use a DOI?
Abstract: Objectives: The aim of our study was to investigate the relationship between glucose metabolism, high sensitivity C-reactive protein (hsCRP), advanced glycation end-products (AGEs) and aortic stiffness in non-diabetic middle aged metabolic syndrome (MetS) subjects.

Methods: We studied a total of 486 non-diabetic subjects (aged 40–65, 61% women) with MetS but without overt atherosclerotic disease. AGEs were measured by skin autofluorescence while aortic stiffness was assessed as carotid to femoral pulse wave velocity (PWV) by applanation tonometry. Glucose metabolism was evaluated by oral glucose tolerance test.

Results: In univariate analysis, log transformed hsCRP were significantly associated with various indices of insulin resistance (r_HOMA-IR =0.20, r_QUICKI =−0.20, p<0.01) and PWV (r=0.17, p<0.01). This association remained significant in a separate analysis of men and women subgroups. The multivariate analysis showed that impact of hsCRP on PWV remains significant after adjustment for age, heart rate, mean blood pressure, insulin resistance indices, smoking and MetS components (p<0.01). In contrast, AGEs measured by skin autofluorescence were not associated neither with indices of insulin resistance (r_HOMA-IR =−0.04, r_QUICKI =0.03) nor PWV (r=0.02). Subjects with impaired vs. normal glucose tolerance had higher PWV (9.33±1.54 vs. 8.67±1.54 m/s) and hsCRP (3.54±3.3 vs. 2.53±2.55 mg/L), but not AGEs (2.11±0.41 vs. 2.17±0.44).

Conclusions: In the middle-aged MetS subjects without diabetes hsCRP but not AGEs measured by skin autofluorescence are related to both altered glucose metabolism and arterial stiffening. Our finding suggests that in early stages of the cardiometabolic disorder prevailing determinant of arterial damage is inflammation, but not tissue glycation.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 128 - 129
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.096 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - L. Ryliskyte
AU  - A. Laucevicius
AU  - J. Badariene
AU  - R. Navickas
AU  - S. Solovjova
PY  - 2013
DA  - 2013/11/11
TI  - P3.08 C-REACTIVE PROTEIN BUT NOT ADVANCED GLYCATION END-PRODUCTS ARE RELATED TO ALTERED GLUCOSE METABOLISM AND ARTERIAL STIFFENING IN THE MIDDLE AGED METABOLIC SYNDROME SUBJECTS: DATA FROM A CROSS SECTIONAL STUDY
JO  - Artery Research
SP  - 128
EP  - 129
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.096
DO  - 10.1016/j.artres.2013.10.096
ID  - Ryliskyte2013
ER  -

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