Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 129 - 129

P3.10 GENETIC FACTORS VS CARDIOVASCULAR RISK FACTORS. WHAT IS MORE SIGNIFICANT IN VASCULAR AGING?

Authors
A.S. Kruglikova, I.D. Strazhesko, E.V. Plokhova, V.S. Pyhtina, D.U. Akasheva, O.U. Isaykina, O.N. Tkacheva, S.A. Boytsov
National Research Center for Preventive Medicine, Moscow, Russian Federation
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.098How to use a DOI?
Abstract

Objective: Telomere length (TL) has been identified as a marker for biological, cardiovascular aging and cardiovascular events risk. Increased arterial stiffness and intima-media thickness (IMT) are the main signs of arterial aging and strong predictors for the development of cardiovascular disease. But the origin of the association between cardiovascular events risk and telomere biology is still unknown. The aim of this study was to determine the role of telomere lenght (a largely inherited component) and conventional cardiovascular risk factors (CVRF) (a largely acquired component) in vascular aging process.

Design: The study group included 146 patients free from established cardiovascular diseases, mean age 51,34 ± 19,02 years. Smoking, arterial hypertension, obesity, dyslipidemia, high fasting glucose level were considered as CVRF.

Methods: TL was assessed by quantitative polymerase chain reaction. IMT was determined by ultrasonography in both left and right carotid arteries. Arterial stiffness was appreciated by aortic pulse wave velocity (PWV) measuring with the help of SphygmoCor (AtCor Medical). Results are summarized in the table.

PWV IMT
TL r = −0,2657 r = −0,1861
p = 0,0096 p = 0,0618
CVFR r = −0,0983 r = 0,2997
p = 0,264 p = 0,0005

Conclusions: TL has strong correlation with PWV, but not IMT. Opposite, the presence of conventional CVRF are contribute to subclinical atherosclerosis, not arterial stiffness. Thus, age-related changes in the vascular wall has different causes and requires an individual approach to the prevention and treatment.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
129 - 129
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.098How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A.S. Kruglikova
AU  - I.D. Strazhesko
AU  - E.V. Plokhova
AU  - V.S. Pyhtina
AU  - D.U. Akasheva
AU  - O.U. Isaykina
AU  - O.N. Tkacheva
AU  - S.A. Boytsov
PY  - 2013
DA  - 2013/11/11
TI  - P3.10 GENETIC FACTORS VS CARDIOVASCULAR RISK FACTORS. WHAT IS MORE SIGNIFICANT IN VASCULAR AGING?
JO  - Artery Research
SP  - 129
EP  - 129
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.098
DO  - 10.1016/j.artres.2013.10.098
ID  - Kruglikova2013
ER  -