P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients

DOI

10.2991/artres.k.191224.169How to use a DOI?

Abstract

Background: Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance.

Purpose: To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients.

Methods: 88 patients (66 women), mean age 61.96 ± 10.15. Cardiovascular risk factors (body weight, waist circumference, lipid fractions, smoking, diabetes, hypertension) and chemerin were assessed. Insulin resistance scores were calculated: Homeostatic model assessment (HOMA) = insulin (μU/mL) * glicemia (mg/dl)/405 and Quantitative insulin sensitivity check index (QUICKI = 1/[lg10 (insulin (μU/mL)) + lg10 (glicemia)]. Patients were categorized in obese only (20.5%), diabetics only (12.5%), obese and diabetics (14.8%) and non-diabetics-non obese (52.3%).

Results: 35.3% patients were obese, 27.3% diabetics, 79.5% hypertensive, 17% current smokers, 67% dyslipidaemic. The values of chemerin registered in the four groups were as follows: in diabetic + obese patients 7.98 ± 7.22 pg/ml (median 5.2), diabetics only 7.27 ± 5.24 pg/ml (5.6), obese only 8.42 ± 7.56 pg/ml (median 5.8), non-obese-non-diabetics 9.15 ± 7.64 pg/ml (median 7.15). Globally chemerin did not correlate with waist circumference, HDL-cholesterol, LDL-cholesterol, glicemia, insulin, HOMA index or QUICKI index. Going further with analysis, no significant correlations were found between chemerin and HOMA index and QUICKI index in diabetic + obese patients, obese only patients, diabetics only. But, in non-obese-non-diabetics significant correlations were found – between chemerin and glicemia (r = 0.3), HOMA index (r = 0.3, p = 0.03), QUICKI index (r = −0.310, p = 0.037), but not with waist circumference (r = 0.224, p = NS), HDL (r = 0.08, p = NS) or LDL (r = −0.06, p = NS).

Conclusion: Although many things need to be elucidated regarding the chemerin mechanism, it seems very probable to be involved in early insulin resistance.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

TY  - JOUR
AU  - Angela Cozma
AU  - Adriana Fodor
AU  - Vasile Negrean
AU  - Dorel Sampelean
AU  - Ionut Minciuna
AU  - Monica Oltean
AU  - Ionela Popovici
AU  - Sorina Coste
AU  - Alexandra Dadarlat
AU  - Dana Pop
AU  - Olga Hilda Orasan
AU  - Adela-Viviana Sitar-Taut
PY  - 2020
DA  - 2020/02/17
TI  - P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients
JO  - Artery Research
SP  - S186
EP  - S186
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.169
DO  - 10.2991/artres.k.191224.169
ID  - Cozma2020
ER  -