P150 Study of Heamodynamic and Macrocirculation Indices Between Uncontrolled Naïve Hypertensives and Well Controlled Diabetic Patients

DOI

10.2991/artres.k.191224.170How to use a DOI?

Abstract

Introduction: Both Type II Diabetes mellitus (DM) and hypertension have been associated with an increased risk for cardiovascular disease and linked to impairments in micro- and macrocirculation. However, previous studies examining micro- and macrocirculation in DM mainly include patients with comorbid hypertension. Therefore, the aim of the study was to compare hemodynamic and vascular indices in DM and non-DM patients, independently of their hypertension status.

Materials and Methods: Fifty-seven DM patients and 79 non-DM participants were enrolled. Participants underwent physical examination, ambulatory BP monitoring and estimation of pulse wave velocity (PWV) and intima-media thickness (IMT). Resting hemodynamic parameters were assessed by impedance cardiography. Participants also performed a 3-min-submaximal isometric handgrip (30% MVC) with continuous beat-by-beat BP/HR assessment (Finapress). The double product (DP = systolic blood pressure* heart rate) during HG was calculated, as an index of myocardial stress.

Results: No differences were observed in age, BMI, and resting BP among groups. Patients with DM had significantly higher PWV and IMT (p < 0.01) but lower velocity (VI) and acceleration index (ACI) compared to non-DM individuals (p < 0.05). Hypertensives had significantly higher myocardial stress during exercise compared to normotensives, independently of the presence of diabetes.

Conclusion: Despite similar blood pressure levels in DM and non-DM groups, the DM patients had higher PWV and IMT than non-DM participants. There were no differences between patients with isolated adequately controlled DM or isolated hypertension in macrocirculation indices, suggesting a possible equal impact of the above diseases on the macrovascular network.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

TY  - JOUR
AU  - Areti Triantafyllou
AU  - Nick Koletsos
AU  - Konstantina Dipla
AU  - Ioanna Zografou
AU  - Xristos Avgerinos
AU  - Stauros Papadopoulos
AU  - Alexandros-Savvas Zafeiridis
AU  - Stella Kritikou
AU  - Eugenia Gkaliagkousi
AU  - Andreas Zafeiridis
AU  - Stella Douma
PY  - 2020
DA  - 2020/02/17
TI  - P150 Study of Heamodynamic and Macrocirculation Indices Between Uncontrolled Naïve Hypertensives and Well Controlled Diabetic Patients
JO  - Artery Research
SP  - S187
EP  - S187
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.170
DO  - 10.2991/artres.k.191224.170
ID  - Triantafyllou2020
ER  -