P148 The Administration of Green Tea Extract Improves Hemodynamic Parameters, Arterial Stiffness and Renal Function in Patients with Diabetic Nephropathy

Marycruz Barocio; Fernando Grover; Mayra Jiménez; Mariana Larios; Patricia Quezada; Jhonatan Trujillo; Ernesto Cardona; David Cardona; Carlos Ramos

doi:10.2991/artres.k.191224.168

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 25, Issue Supplement 1, December 2019, Pages S185 - S185

P148 The Administration of Green Tea Extract Improves Hemodynamic Parameters, Arterial Stiffness and Renal Function in Patients with Diabetic Nephropathy

Authors

Marycruz Barocio^*, Fernando Grover, Mayra Jiménez, Mariana Larios, Patricia Quezada, Jhonatan Trujillo, Ernesto Cardona, David Cardona, Carlos Ramos

University of Guadalajara, Guadalajara, Mexico

^*Corresponding author. Email: marycruz_bp91@hotmail.com

Corresponding Author

Marycruz Barocio

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.168 How to use a DOI?
Abstract: Purpose/Background/Objectives: Type 2 Diabetes Mellitus (T2DM) is a disease characterized by macro and microvascular complications, particularly, coronary heart disease, cerebrovascular disease and nephropathy [1–4]. The green tea extract has shown an anti-inflammatory effect (2), so this nutraceutical could be an alternative adjuvant in the treatment of the patient with diabetic nephropathy (DN) [5–7]. To evaluate the effect of the administration of green tea extract on hemodynamic, arterial stiffness, metabolic and renal function parameters in patients with DN.

Design and Methods: It was a randomized, double-blind study performed in 28 patients with DN, 14 assigned to placebo and 14 green tea extract, 400 mg every 12 hours for 12 weeks. Hemodynamic and arterial stiffness parameters were determined with HEM-9000AI, VP1000 Omron and metabolic parameters and renal function with Erba XL-100 equipment.

Results: The group under green tea extract treatment had significant decrease in the systolic blood pressure (mmHg) compared to those under placebo (−4.3 ± 12.7 vs 5.4 ± 12.2), central pressure (mmHg) (−6.0 ± 13.4 vs 9.1 ± 14.4), pulse pressure (mmHg) (−3.5 ± 6.6 vs 3.3 ± 6.4), triglycerides (mg/dl) (−16.4 ± 46.7 vs 30.3 ± 35.9), creatinine (−1.3 ± 0.2 vs 0.1 ± 0.1) and GFR (ml/min/1.73 m²) [8] (6.2 ± 5.9 vs −7.7 ± 10.9).

Conclusion: The administration of green tea extract improves hemodynamic parameters, metabolic parameters and renal function in patients with DM2 and chronic kidney disease.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]L Chen, DJ Magliano, and PZ Zimmet, The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives, Nat Rev Endocrinol, Vol. 8, 2011, pp. 228-36.

[2]RC Rosales-Gómez, JJ López-Jiménez, NY Núñez-Reveles, AE González-Santiago, and SA Ramírez-García, Nefropatía por diabetes mellitus tipo 2: un rasgo multifactorial con umbral y su mapa mórbido cromosómico, Rev Med Inst Mex Seguro Soc, Vol. 48, 2010, pp. 521-30.

[3]N Han Cho, J Kirigia, JC Mbanya, K Ogurstova, L Guariguata, W Rathmann, et al., Diabetes atlas de la FID, 8a edición, 2017.

[4]HJ Heerspink, BA Perkins, DH Fitchett, M Husain, and DZ Cherney, Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications, Circulation, Vol. 134, 2016, pp. 752-72.

[5]C Adamopoulos, C Mihailidou, C Grivaki, KA Papavassiliou, H Kiaris, C Piperi, et al., Systemic effects of AGEs in ER stress induction in vivo, Glycoconj J, Vol. 33, 2016, pp. 537-44.

[6]KR Tuttle, JL Bruton, MC Perusek, JL Lancaster, DT Kopp, and RA DeFronzo, Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus, N Engl J Med, Vol. 324, 1991, pp. 1626-32.

[7]CS Yang, L Chen, MJ Lee, D Balentine, MC Kuo, and SP Schantz, Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers, Cancer Epidemiol Biomarkers Prev, Vol. 7, 1998, pp. 351-4.

[8]AS Levey, LA Stevens, CH Schmid, YL Zhang, AF Castro, HI Feldman, et al., A new equation to estimate glomerular filtration rate, Ann Intern Med, Vol. 150, 2009, pp. 604-12.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S185 - S185
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.168 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Marycruz Barocio
AU  - Fernando Grover
AU  - Mayra Jiménez
AU  - Mariana Larios
AU  - Patricia Quezada
AU  - Jhonatan Trujillo
AU  - Ernesto Cardona
AU  - David Cardona
AU  - Carlos Ramos
PY  - 2020
DA  - 2020/02/17
TI  - P148 The Administration of Green Tea Extract Improves Hemodynamic Parameters, Arterial Stiffness and Renal Function in Patients with Diabetic Nephropathy
JO  - Artery Research
SP  - S185
EP  - S185
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.168
DO  - 10.2991/artres.k.191224.168
ID  - Barocio2020
ER  -

download .riscopy to clipboard