P151 Microvascular Dysfunction is Associated with Impaired Beta-cell Function: The Maastricht Study

Wenjie Li; Alfons Houben; Tos Berendschot; Carroll Webers; Abraham Kroon; Marleen van Greevenbroek; Carla van der Kallen; Ronald Henry; Simone Sep; Pieter Dagnelie; Nicolaas Schaper; Simone Eussen; Casper Schalkwijk; Miranda Schram; Coen Stehouwer

doi:10.2991/artres.k.191224.171

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Volume 25, Issue Supplement 1, December 2019, Pages S188 - S188

P151 Microvascular Dysfunction is Associated with Impaired Beta-cell Function: The Maastricht Study

Authors

Wenjie Li, Alfons Houben, Tos Berendschot, Carroll Webers, Abraham Kroon, Marleen van Greevenbroek, Carla van der Kallen, Ronald Henry, Simone Sep, Pieter Dagnelie, Nicolaas Schaper, Simone Eussen, Casper Schalkwijk, Miranda Schram, Coen Stehouwer

Maastricht University Medical Center, Maastricht, The Netherlands

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.171 How to use a DOI?
Abstract: Background: The pathophysiological mechanism underlying beta-cell dysfunction in type 2 diabetes (T2D) is not fully understood. Recent animal studies suggest that microvascular dysfunction (MVD) may lead to insufficient delivery of oxygen and nutrients to beta-cells as well as an attenuated delivery of insulin into the circulation [1,2]. We aimed to investigate the association of MVD with beta-cell function in a population-based cohort study.

Methods: In The Maastricht Study (n = 2802, 51.5% men, aged 59.8 + 8.2 years, 22.9% T2D) [3], we determined plasma endothelial biomarkers (vWF, sE-selectin, sICAM-1, sVCAM-1), retinal microvascular diameters (CRAE, CRVE), flicker light-induced retinal microvascular dilation (DVA), heat-induced skin hyperaemia (LDF), and beta-cell function (OGTT: C-peptide to glucose ratio t0 (CP0/G0 ratio), CP30/G30 ratio, CP120/G120 ratio, beta-cell glucose sensitivity, potentiation, and rate sensitivity). Associations were adjusted for age, sex, waist circumference, systolic blood pressure, smoking, alcohol intake, lipid profile, use of antihypertensive and/or lipid-modifying drugs, and Matsuda index.

Results: Multivariable adjusted analyses showed that a higher levels of plasma endothelial biomarkers and wider retinal venules (CRVE) were associated with greater CP0/G0 ratio (stB = 0.13, 95% CI (0.10; 0.16), p < 0.001; stB = 0.03, (0.003; 0.07), p = 0.031, respectively; Figure 1). Lower flicker light-induced retinal arteriolar dilation (%) was associated with lower CP30/G30 ratio (stB = 0.06, (0.01; 0.10), p = 0.011) and beta-cell glucose sensitivity (stB = 0.05, (0.01; 0.10), p = 0.025). Lower heat-induced skin hyperaemia (%) was associated with lower beta-cell glucose sensitivity (stB = 0.06, (0.003; 0.11), p = 0.038).

Conclusion: MVD is associated with higher fasting insulin secretion, and lower CP30/G30 ratio and beta-cell glucose sensitivity during OGTT. These results suggest that MVD may contribute to an augmented fasting insulin secretion as well as attenuated insulin secretion during OGTT. This may contribute to beta-cell failure.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]S Hashimoto, N Kubota, H Sato, M Sasaki, I Takamoto, T Kubota, et al., Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion, Diabetes, Vol. 64, 2015, pp. 876-86.

[2]E Kostromina, X Wang, and W Han, Altered islet morphology but normal islet secretory function in vitro in a mouse model with microvascular alterations in the pancreas, PLoS One, Vol. 8, 2013, pp. e71277.

[3]MT Schram, SJ Sep, CJ van der Kallen, PC Dagnelie, A Koster, N Schaper, et al., The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities, Eur J Epidemiol, Vol. 29, 2014, pp. 439-51.

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S188 - S188
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.171 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Wenjie Li
AU  - Alfons Houben
AU  - Tos Berendschot
AU  - Carroll Webers
AU  - Abraham Kroon
AU  - Marleen van Greevenbroek
AU  - Carla van der Kallen
AU  - Ronald Henry
AU  - Simone Sep
AU  - Pieter Dagnelie
AU  - Nicolaas Schaper
AU  - Simone Eussen
AU  - Casper Schalkwijk
AU  - Miranda Schram
AU  - Coen Stehouwer
PY  - 2020
DA  - 2020/02/17
TI  - P151 Microvascular Dysfunction is Associated with Impaired Beta-cell Function: The Maastricht Study
JO  - Artery Research
SP  - S188
EP  - S188
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.171
DO  - 10.2991/artres.k.191224.171
ID  - Li2020
ER  -

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