P154 VASCULAR STRUCTURE AND FUNCTION IN RELATION TO WEIGHT EXCESS AND BLOOD PRESSURE IN A SAMPLE OF OBESE CHILDREN

Sara Bonafini; Angela Tagetti; Francesco Dalle Vedove; Sara Raimondi; Alice Giontella; Paolo Cavarzere; Rossella Gaudino; Pietro Minuz; Claudio Maffeis; Franco Antoniazzi; Cristiano Fava

doi:10.1016/j.artres.2017.10.175

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Volume 20, Issue C, December 2017, Pages 103 - 103

P154 VASCULAR STRUCTURE AND FUNCTION IN RELATION TO WEIGHT EXCESS AND BLOOD PRESSURE IN A SAMPLE OF OBESE CHILDREN

Authors

Sara Bonafini¹, Angela Tagetti¹, Francesco Dalle Vedove¹, Sara Raimondi¹, Alice Giontella¹, Paolo Cavarzere², Rossella Gaudino², Pietro Minuz¹, Claudio Maffeis², Franco Antoniazzi², Cristiano Fava¹

¹University of Verona, Department of Medicine, Italy

²University of Verona, Department of Surgery, Dentistry, Paediatrics and Gynaecology, Italy

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.175 How to use a DOI?
Abstract: Objective: To investigate the influence of weight excess and blood pressure (BP) on vascular structure and function in a sample of obese children.

Methods: We measured office and ambulatory BP (ABPM), carotid intima-media thickness (cIMT), endothelial function by the Flow Mediated Dilation (FMD) technique, carotid distensibility (cDC) (ultrasonograph: LogiQ P5 Pro; software: Multimedia Video Engine II, DSP Lab, Pisa CNR, Italy) (1) and stiffness index (SI) by photopletismography (Pulce Trace PT1000, MicroMedical Ltd, UK) (2) in overweight and obese children (BMI > 90th percentile for sex and age).

Results: Seventy children with weight excess were enrolled (age 11.5±2.4 years; female n: 30). cDC showed inverse correlation with BMI and waist circumference (r_Spearman = −0.403 and r_s = −0.346, respectively), 24h-SBP (r_s = −0.449) and nighttime-SBP (r_s = −0.490). SI inversely correlated with BMI (r_s = −0.359) and waist/height ratio (r_s = −0.303). When comparing normotensive and hypertensive children, as defined on the basis of the ABPM, no significant differences in vascular tests were found, although cDC tended to be lower in hypertensive. In normotensive subjects (n: 53) cIMT directly correlated with nighttime-SBP and DBP. Most of the correlations remained significant after adjustment for age, sex, BMI and BP.

Conclusions: These data suggest that arterial elasticity is negatively affected by weight excess and 24h-BP levels even in childhood. In the normotensive subgroup it is detectable an effect of BP also on arterial structure.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 103 - 103
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.175 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Sara Bonafini
AU  - Angela Tagetti
AU  - Francesco Dalle Vedove
AU  - Sara Raimondi
AU  - Alice Giontella
AU  - Paolo Cavarzere
AU  - Rossella Gaudino
AU  - Pietro Minuz
AU  - Claudio Maffeis
AU  - Franco Antoniazzi
AU  - Cristiano Fava
PY  - 2017
DA  - 2017/12/06
TI  - P154 VASCULAR STRUCTURE AND FUNCTION IN RELATION TO WEIGHT EXCESS AND BLOOD PRESSURE IN A SAMPLE OF OBESE CHILDREN
JO  - Artery Research
SP  - 103
EP  - 103
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.175
DO  - 10.1016/j.artres.2017.10.175
ID  - Bonafini2017
ER  -

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