P153 MARKER OF TYPE VI COLLAGEN FORMATION (PRO-C6) IS ASSOCIATED WITH HIGHER ARTERIAL STIFFNESS IN TYPE 1 DIABETES

DOI

10.1016/j.artres.2017.10.174How to use a DOI?

Abstract

Aim: Arterial stiffening reflects fragmentation and loss of elastin fibers and accumulation of stiffer collagen fibers in the media of large arteries. We evaluated associations between carotid-femoral pulse wave velocity (cfPWV) and a marker of collagen type VI formation (Pro-C6) and a marker of collagen type III degradation (C3M) in type 1 diabetes.

Methods: Serum and urinary level of Pro-C6 and C3M was measured with ELISA in 634 patients with type 1 diabetes. cfPWV was assessed by the SphygmoCor device. We applied unadjusted and adjusted linear regression analyses. Adjustment included sex, age, mean arterial pressure, LDL cholesterol, smoking, HbA_1c, eGFR and urinary albumin excretion rate. To adjust for urine output levels, the urinary markers were normalized for urinary creatinine.

Results: Of the 634 patients, 349 (55%) were male, mean±SD age was 54.6±12.6 years and cfPWV 10.4±3.3 m/s.

Higher serum and urinary level of Pro-C6 was associated with higher cfPWV in unadjusted models (p≤0.039), after adjustment only higher serum level remained significantly associated with higher cfPWV (β estimate per doubling: 0.47±0.21; p = 0.028).

Lower urinary level of C3M was associated with higher cfPWV in the unadjusted model (p < 0.001), but significance was lost after adjustment (p = 0.44). Higher serum level of C3M was associated with higher cfPWV in the unadjusted model (p = 0.002), but significance was lost after adjustment (p = 0.34).

Conclusion: In type 1 diabetes, higher serum levels of Pro-C6, a marker of collagen type VI formation, was associated with increased arterial stiffness. This observation could introduce a new target for therapeutic intervention.

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TY  - JOUR
AU  - Tine Willum Hansen
AU  - Daniel G.K. Rasmussen
AU  - Simone Theilade
AU  - Signe H. Nielsen
AU  - Morten A. Karsdal
AU  - Federica Genovese
AU  - Peter Rossing
PY  - 2017
DA  - 2017/12/06
TI  - P153 MARKER OF TYPE VI COLLAGEN FORMATION (PRO-C6) IS ASSOCIATED WITH HIGHER ARTERIAL STIFFNESS IN TYPE 1 DIABETES
JO  - Artery Research
SP  - 103
EP  - 103
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.174
DO  - 10.1016/j.artres.2017.10.174
ID  - Hansen2017
ER  -