Artery Research

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Volume 20, Issue C, December 2017, Pages 103 - 103

P154 VASCULAR STRUCTURE AND FUNCTION IN RELATION TO WEIGHT EXCESS AND BLOOD PRESSURE IN A SAMPLE OF OBESE CHILDREN

Authors
Sara Bonafini1, Angela Tagetti1, Francesco Dalle Vedove1, Sara Raimondi1, Alice Giontella1, Paolo Cavarzere2, Rossella Gaudino2, Pietro Minuz1, Claudio Maffeis2, Franco Antoniazzi2, Cristiano Fava1
1University of Verona, Department of Medicine, Italy
2University of Verona, Department of Surgery, Dentistry, Paediatrics and Gynaecology, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.175How to use a DOI?
Abstract

Objective: To investigate the influence of weight excess and blood pressure (BP) on vascular structure and function in a sample of obese children.

Methods: We measured office and ambulatory BP (ABPM), carotid intima-media thickness (cIMT), endothelial function by the Flow Mediated Dilation (FMD) technique, carotid distensibility (cDC) (ultrasonograph: LogiQ P5 Pro; software: Multimedia Video Engine II, DSP Lab, Pisa CNR, Italy) (1) and stiffness index (SI) by photopletismography (Pulce Trace PT1000, MicroMedical Ltd, UK) (2) in overweight and obese children (BMI > 90th percentile for sex and age).

Results: Seventy children with weight excess were enrolled (age 11.5±2.4 years; female n: 30). cDC showed inverse correlation with BMI and waist circumference (rSpearman = −0.403 and rs = −0.346, respectively), 24h-SBP (rs = −0.449) and nighttime-SBP (rs = −0.490). SI inversely correlated with BMI (rs = −0.359) and waist/height ratio (rs = −0.303). When comparing normotensive and hypertensive children, as defined on the basis of the ABPM, no significant differences in vascular tests were found, although cDC tended to be lower in hypertensive. In normotensive subjects (n: 53) cIMT directly correlated with nighttime-SBP and DBP. Most of the correlations remained significant after adjustment for age, sex, BMI and BP.

Conclusions: These data suggest that arterial elasticity is negatively affected by weight excess and 24h-BP levels even in childhood. In the normotensive subgroup it is detectable an effect of BP also on arterial structure.

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This is an open access article distributed under the CC BY-NC license.

References

(1)A Doyon et al., Carotid Artery Intima-Media Thickness and Distesibility in Children and Adolescents: Reference Values and Role of Body Dimension, Hypertension, Vol. 62, 2013, pp. 550-556.
(2)SC Millesseau et al., Determination of age-related increases in large artery stiffness by digital pulse contour analysis, Clin Sci (Lond), Vol. 103, 2002, pp. 371-7.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
103 - 103
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.175How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Sara Bonafini
AU  - Angela Tagetti
AU  - Francesco Dalle Vedove
AU  - Sara Raimondi
AU  - Alice Giontella
AU  - Paolo Cavarzere
AU  - Rossella Gaudino
AU  - Pietro Minuz
AU  - Claudio Maffeis
AU  - Franco Antoniazzi
AU  - Cristiano Fava
PY  - 2017
DA  - 2017/12/06
TI  - P154 VASCULAR STRUCTURE AND FUNCTION IN RELATION TO WEIGHT EXCESS AND BLOOD PRESSURE IN A SAMPLE OF OBESE CHILDREN
JO  - Artery Research
SP  - 103
EP  - 103
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.175
DO  - 10.1016/j.artres.2017.10.175
ID  - Bonafini2017
ER  -