P114 ARTERIAL STIFFNESS IS ASSOCIATED WITH AMBULATORY BLOOD PRESSURE PARAMETERS IN PATIENTS ON MAINTENANCE HEMODIALISYS
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- Abstract
Introduction: Arterial stiffness is a principal pathogenetic mechanism of aortic systolic blood pressure (SBP) augmentation, left ventricular hypertrophy and sudden cardiac death. The aim of the study was to evaluate the association between parameters of pulse wave and 44-hour ambulatory blood pressure (ABP) variables in patients with end- stage renal disease.
Methods: In 68 patients with ESRD on maintenance hemodialysis (45.6% males, median age 58.3(interquartile range (IQR) 54.6; 61.6) years, dialysis duration 62.7(47.8; 77) months applanation tonometry and 44-hour ABP monitoring was performed.
Results: Carotid-femoral pulse wave velocity (PWV) < 10 vs PWV≥10m/s was revealed in 52(76.5%) of patients respectively. Patients with PWV≥10 vs < 10 m/s had higher dialysis duration (median 60; IQR 36; 84) vs 28; IQR 11; 50.5) months, p < 0.05), peripheral SBP (148.1±24,8 vs 140.7±23,6 mmHg, p < 0.05); diastolic blood pressure (DBP) (85.7±15,2 vs 83.3±12,7 mmHg, p < 0.05); 48-hour heart rate (HR) (74.7±13,0 vs 72±8,7 bpm, p < 0.05), mean day one HR (78.7±7,5 vs 72.5±9,7 bpm, p < 0.05), 48- hour DBP variability (DBPV) (78±13 vs 88±12 mmHg, p < 0.01), day two SBP variability (13.5±4,4 vs 13.1±4,1) mmHg, p < 0.05), mean day two BD variability (12±3,9 vs median 11; 11.8±3,6) mmHg, p < 0.05).
Patients with PWV≥10 vs <10 m/s had lower daytime DBPV (median 8.5; IQR 7; 9) vs IQR 10 (8; 11) mmHg, p < 0.05), day one DBPV (median 8; IQR 8; 9) vs 9 IQR 8; 10 mmHg, p < 0.01).
Conclusions: Patients with PWV≥10 m/s had higher duration of dialysis, higher values of ambulatory DBP and higher – of HR. These findings may have implications in gaining further insights into the mechanism of arterial stiffness.
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TY - JOUR AU - Maria Trukhanova AU - Nadezhda Manukhina AU - Dmitry Doroshenko AU - Svetlana Villevalde AU - Zhanna Kobalava PY - 2017 DA - 2017/12/06 TI - P114 ARTERIAL STIFFNESS IS ASSOCIATED WITH AMBULATORY BLOOD PRESSURE PARAMETERS IN PATIENTS ON MAINTENANCE HEMODIALISYS JO - Artery Research SP - 93 EP - 93 VL - 20 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.10.145 DO - 10.1016/j.artres.2017.10.145 ID - Trukhanova2017 ER -