Artery Research

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Volume 20, Issue C, December 2017, Pages 93 - 93

P115 ALBUMIN-TO-CREATININE RATIO IS ASSOCIATED WITH TARGET ORGAN DAMAGE IN HYPERTENSION

Authors
Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Nikolaos Loakeimidis, Christos Georgakopoulos, Konstantinos Aznaouridis, Panagiotis Xaplanteris, Athanasios Angelis, Dimitrios Tousoulis
Peripheral Vessels Unit, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.146How to use a DOI?
Abstract

Purpose/Background/Objectives: Hypertension is associated with higher cardiovascular risk as well as several markers of subclinical target organ damage (TOD). Albumin to creatinine ratio (ACR) in urine has been recognised as an independent risk factor for cardiovascular events. We hypothesised that there is a relationship between ACR and markers of TOD in never- treated hypertensives.

Methods: We enrolled 924 consecutive essential hypertensives (mean age 53±12 years, 486 males) without known cardiovascular disease (CVD). Markers of subclinical TOD [left ventricular mass index (LVMI), pulse wave velocity (PWV), ankle-brachial index (ABI) and estimated glomerular filtration rate (eGFR)] were evaluated in all patients. LVMI was assessed echocardiographically using the Devereux formula. Carotid-femoral PWV was estimated with the Complior device. eGFR was calculated by the Cockcroft-Gault formula. ABI was calculated by dividing the highest ankle systolic blood pressure by the highest brachial systolic blood pressure.

Results: ACR exhibited significant association with LVMI (r = 0.277, p < 0.001), PWV (r = 0.277, p < 0.001) ABI (r = −0.078, p = 0.018) and eGFR (r = −0.100, p = 0.002). In further analysis, ACR was associated with TOD as suggested by the 2013 European Guidelines for Hypertension [left ventricular hypertrophy (LVMI > 115 g/m2 in men and >95 g/m2 in women), increased PWV (PWV > 10m/s), decreased ABI (ABI < 0.9) and decreased renal function (eGFR < 60ml/min)]. Specifically, ACR exhibited a significant association with the number of TOD and this association was independent of age and gender (p < 0.05).

Conclusions: Our findings support the close relationship between ACR and TOD in hypertension, as well as, the predictive ability of ACR for TOD.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
93 - 93
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.146How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Losif Koutagiar
AU  - Charalambos Vlachopoulos
AU  - Dimitrios Terentes-Printzios
AU  - Nikolaos Loakeimidis
AU  - Christos Georgakopoulos
AU  - Konstantinos Aznaouridis
AU  - Panagiotis Xaplanteris
AU  - Athanasios Angelis
AU  - Dimitrios Tousoulis
PY  - 2017
DA  - 2017/12/06
TI  - P115 ALBUMIN-TO-CREATININE RATIO IS ASSOCIATED WITH TARGET ORGAN DAMAGE IN HYPERTENSION
JO  - Artery Research
SP  - 93
EP  - 93
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.146
DO  - 10.1016/j.artres.2017.10.146
ID  - Koutagiar2017
ER  -