P112 CENTRAL PULSE WAVE PARAMETERS ARE ASSOCIATED WITH VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE ON MAINTENANCE HEMODIALYSIS

DOI

10.1016/j.artres.2017.10.143How to use a DOI?

Abstract

Background: Arterial stiffness is known marker of poor cardiovascular prognosis. The aim if the study was to assess the incidence of valve calcification (VC) in patients with end- stage renal disease (ESRD) and its associations with clinical parameters of arterial stiffness.

Methods: In 68 adults with ESRD on maintenance hemodialysis for >3 months (45.6% males, median age 58.3 (interquartile range (IQR) 54.6; 61.6) years, dialysis duration 62.7 (47.8; 77) months, echocardiography and applanation tonometry was performed.

Results: Calcification of the aortic, mitral and both valves was revealed in 46 (67.6%), 34 (50%) and 33 (48.5%) of patients. 20 (29%) patients had no signs of VC. Patients with vs without AVC were older (65.1±9.5 vs 41.4±11,9 years, p < 0.001), had higher dialysis duration (51 (8; 252) vs 21 (10; 38) months, p < 0.01), lower peripheral diastolic blood pressure (DBP) (76±17 vs 84±12 mmHg, p < 0.05), central DBP (75±15 vs 82±11 mmHg, p < 0.05), reflected wave transit time (RWTT) (131±17 vs 137±15 ms, p < 0.05). Patients with vs without MVC were older (67.8±8.2 vs 47.9±13,5 years, p < 0.001), had higher dialysis duration (51 (34; 111) vs 36 (14; 57) months, p < 0.01), carotid-femoral pulse wave velocity (10.1±2.7 vs 8.9±3.5 m/s, p < 0.05), lower peripheral DBP (73±17 vs 84±14 mmHg, p < 0.01), central DBP (72±13 vs 83±13 mmHg, p < 0.001), higher central pulse pressure (52±13 vs 45±16 mmHg, p < 0.05), lower RWTT (133 (120; 130) vs 135 (132; 142) ms, p < 0.05).

Conclusion: High prevalence of VC (71%) was revealed in patients with ESRD on maintenance hemodialysis. Patients with vs without VC were older, had higher duration of dialysis and more pronounced arterial stiffness.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Maria Trukhanova
AU  - Nadezhda Manukhina
AU  - Dmitry Doroshenko
AU  - Svetlana Villevalde
AU  - Zhanna Kobalava
PY  - 2017
DA  - 2017/12/06
TI  - P112 CENTRAL PULSE WAVE PARAMETERS ARE ASSOCIATED WITH VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE ON MAINTENANCE HEMODIALYSIS
JO  - Artery Research
SP  - 92
EP  - 93
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.143
DO  - 10.1016/j.artres.2017.10.143
ID  - Trukhanova2017
ER  -