P111 ASSOCIATION AND CLINICAL RELEVANCE OF ABSENCE OF LOWER LIMB ARTERIAL PULSE AND CORONARY ARTERY DISEASE IN HEMODIALYSIS PATIENTS

Luiz Bortolotto; Felizardo Nataniel; Luis Gowdak; Henrique Muela; Flavio Paula; Elias David-Neto; Jose Jayme De Lima

doi:10.1016/j.artres.2017.10.142

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Volume 20, Issue C, December 2017, Pages 92 - 92

P111 ASSOCIATION AND CLINICAL RELEVANCE OF ABSENCE OF LOWER LIMB ARTERIAL PULSE AND CORONARY ARTERY DISEASE IN HEMODIALYSIS PATIENTS

Authors

Luiz Bortolotto¹, Felizardo Nataniel², Luis Gowdak³, Henrique Muela², Flavio Paula⁴, Elias David-Neto⁴, Jose Jayme De Lima²

¹Hypertension Unity (Heart Institute), Hospital das Clinicas da FMUSP, Brazil

²Hypertension Unity, Heart Institute (InCor), Hospital das Clinicas da FMUSP, Brazil

³Heart Institute (InCor), Hospital das Clinicas da FMUSP, Brazil

⁴Kidney Transplantation Unity, Hospital das Clinicas da FMUSP, Brazil

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.142 How to use a DOI?
Abstract: Objectives: To determine the association between PAD and DAC in patients treated by haemodialysis in the waiting list for renal transplantation and to assert the influence of that association on prognosis and clinical management.

Methods: 1246 renal transplant candidates underwent coronary angiography. Peripheral artery disease was defined as either absence of pulse in the lower limb or a history of gangrene, amputation, or vascular intervention.

Results: The prevalence of peripheral artery disease and coronary artery disease were 34% and 52%, respectively. The association of peripheral artery disease with coronary artery disease was significant (68% versus 32%, OR = 2.60, 95% CI 2.03–3.32, P = .0001). The specificity, sensitivity, positive predictive value, and negative predictive value were 77%, 44%, 67%, and 56%, respectively. Peripheral artery disease predicted the indication of coronary intervention. Patients lacking peripheral artery disease and coronary artery disease enjoyed higher event-free survival. Peripheral artery disease and coronary artery disease together did not add to the very high cardiovascular risk associated with each isolated condition. Death by any cause was influenced by peripheral artery disease independently of coronary artery disease.

Conclusions: A safe and inexpensive clinical method was useful to assess the association between PAD and CAD and may be useful to select patients for invasive studies. PAD was equivalent to CAD as a predictor of cardiovascular prognosis. Combining coronary and PAD evaluation helps to assess the prognosis of patients with CKD with reasonable accuracy.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 92 - 92
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.142 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Luiz Bortolotto
AU  - Felizardo Nataniel
AU  - Luis Gowdak
AU  - Henrique Muela
AU  - Flavio Paula
AU  - Elias David-Neto
AU  - Jose Jayme De Lima
PY  - 2017
DA  - 2017/12/06
TI  - P111 ASSOCIATION AND CLINICAL RELEVANCE OF ABSENCE OF LOWER LIMB ARTERIAL PULSE AND CORONARY ARTERY DISEASE IN HEMODIALYSIS PATIENTS
JO  - Artery Research
SP  - 92
EP  - 92
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.142
DO  - 10.1016/j.artres.2017.10.142
ID  - Bortolotto2017
ER  -

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