Artery Research

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Volume 20, Issue C, December 2017, Pages 85 - 85

P172 VOLUNTARY LIQUORICE INGESTION INCREASES BLOOD PRESSURE VIA MULTIPLE MECHANISMS: INCREASED VOLUME LOAD, PERIPHERAL ARTERIAL RESISTANCE, AND DECREASED AORTIC COMPLIANCE

Authors
Elina J. Hautaniemi1, Anna M. Tahvanainen1, 2, Jenni K. Koskela1, 2, Antti J. Tikkakoski1, 3, Mika Kähönen1, 3, Marko Uitto1, Kalle Sipilä3, Onni Niemelä1, 4, Jukka Mustonen1, 2, Ilkka H. Pörsti1, 2
1Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
2Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
3Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
4Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital, Seinäjoki, Finland
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.120How to use a DOI?
Abstract

Objectives: Liquorice consumption elevates blood pressure [1–3], but the liquorice-induced haemodynamic changes in the upright position are unknown. We investigated haemodynamics after liquorice exposure in healthy volunteers during orthostatic challenge.

Methods: Haemodynamics were recorded from 22 normotensive subjects during passive 10- minute head-up tilt before and after two weeks of liquorice consumption (glycyrrhizin dose 290–370 mg/day) using radial pulse wave analysis, whole-body impedance cardiography, and spectral analysis of heart rate variability. Thirty age-matched healthy subjects maintaining their habitual diet served as controls.

Results: Liquorice ingestion elevated radial systolic (p < 0.001) and diastolic (p = 0.018) blood pressure and systemic vascular resistance (p = 0.037). During orthostatic challenge, heart rate increased less after the liquorice versus control diet (p = 0.003) and low frequency power of heart rate variability decreased within the liquorice group (p = 0.034). Liquorice intake increased central pulse pressure (p < 0.001) and augmentation index (p = 0.002) supine and upright, but in the upright position the elevation of augmentation index was accentuated (p = 0.007). Liquorice diet also increased extracellular fluid volume (p = 0.024) and aortic to popliteal pulse wave velocity (p = 0.027), and aortic characteristic impedance in the upright position (p = 0.002).

Conclusions: In addition to increased extracellular fluid volume and large arterial stiffness, two weeks of liquorice ingestion elevated systemic vascular resistance and augmentation index. Measurements performed at rest may underestimate the haemodynamic effects of liquorice ingestion, as enhanced central wave reflection and reduced chronotropic response were especially observed in the upright position.

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This is an open access article distributed under the CC BY-NC license.

References

1.RV Farese Jr, EG Biglieri, CH Shackleton, I Irony, and R Gomez-Fontes, Licorice- induced hypermineralocorticoidism, N Engl J Med, Vol. 325, 1991, pp. 1223-1227.
2.MH Leskinen, EJ Hautaniemi, AM Tahvanainen, JK Koskela, M Päällysaho, AJ Tikkakoski, et al., Daily liquorice consumption for two weeks increases augmentation index and central systolic and diastolic blood pressure, PLoS One, Vol. 9, 2014, pp. e105607.
3.HA Sigurjonsdottir, L Franzson, K Manhem, J Ragnarsson, G Sigurdsson, and S Wallerstedt, Liquorice-induced rise in blood pressure: a linear dose-response relationship, J Hum Hypertens, Vol. 15, 2001, pp. 549-552.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
85 - 85
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.120How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Elina J. Hautaniemi
AU  - Anna M. Tahvanainen
AU  - Jenni K. Koskela
AU  - Antti J. Tikkakoski
AU  - Mika Kähönen
AU  - Marko Uitto
AU  - Kalle Sipilä
AU  - Onni Niemelä
AU  - Jukka Mustonen
AU  - Ilkka H. Pörsti
PY  - 2017
DA  - 2017/12/06
TI  - P172 VOLUNTARY LIQUORICE INGESTION INCREASES BLOOD PRESSURE VIA MULTIPLE MECHANISMS: INCREASED VOLUME LOAD, PERIPHERAL ARTERIAL RESISTANCE, AND DECREASED AORTIC COMPLIANCE
JO  - Artery Research
SP  - 85
EP  - 85
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.120
DO  - 10.1016/j.artres.2017.10.120
ID  - Hautaniemi2017
ER  -