Artery Research

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Volume 20, Issue C, December 2017, Pages 84 - 85

P171 COMPLIANCE OF EXTREMELY DILATED MAIN PULMONARY ARTERIES IN PULMONARY ARTERIAL HYPERTENSION

Authors
Joanne Groeneveldt1, Tijmen van der Wel1, Tim Marcus1, Frances De Man1, Anton Vonk Noordegraaf1, Nicolaas Westerhof1, Berend Westerhof1, 2
1Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
2Department of Medical Biology, Section Systems Physiology, Laboratory for Clinical Cardiovascular Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.119How to use a DOI?
Abstract

Background: Main pulmonary artery (MPA) dilation is a radiological sign of pulmonary hypertension (PH) and is an independent risk factor of sudden death (Żyłkowska et al, Chest 2012). Extreme MPA dilation is a rare consequence of PH. We hypothesize that the main pulmonary artery compliance is larger and contributes more to total arterial compliance in PH patients with an extremely dilated MPA when compared to patients with a less dilated MPA.

Methods: Cardiac magnetic imaging (CMR) scans of idiopathic and hereditary pulmonary arterial hypertension (PAH) patients were retrospectively analyzed. Six PAH patients with extremely dilated MPAs (≥45 mm diameter on transverse plain CMR images of the MPA) and six PAH patients with MPA diameter <45 mm were included. Total pulmonary arterial compliance (Ctot) was calculated by stroke volume (SV) over pulse pressure (PP) and MPA compliance (CMPA) by (Δarea*length)/PP (length was assumed 5 cm for all MPAs). CMPA/Ctot ratio could therefore be calculated by CMR derived flow images alone: CMPA/Ctot = (Δarea*length)/SV.

Results: Mean age in both groups was not different, mean pulmonary artery pressure was higher in patients with an extremely dilated MPA (73±9.0 mmHg) compared to patients with non-extremely dilated MPA (48±5.4 mmHg, p = 0.02). A trend toward a higher CMPA/Ctot ratio was observed in patients with extremely dilated MPA (p = 0.0534).

Conclusion: In PAH the contribution of the MPA to total compliance tends to be higher in patients with a MPA diameter ≥45 mm then in patients with a diameter <45mm.

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This is an open access article distributed under the CC BY-NC license.

References

1.J Żyłkowska, M Kurzyna, M Florczyk, B Burakowska, F Grzegorczyk, J Burakowski, M Wieteska, K Oniszh, A Biederman, L Wawrzyńska, M Szturmowicz, A Fijałkowska, and A Torbicki, Pulmonary artery dilatation correlates with the risk of unexpected death in chronic arterial or thromboembolic pulmonary hypertension, Chest, Vol. 142, 2012, pp. 1406-1416.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
84 - 85
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.119How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Joanne Groeneveldt
AU  - Tijmen van der Wel
AU  - Tim Marcus
AU  - Frances De Man
AU  - Anton Vonk Noordegraaf
AU  - Nicolaas Westerhof
AU  - Berend Westerhof
PY  - 2017
DA  - 2017/12/06
TI  - P171 COMPLIANCE OF EXTREMELY DILATED MAIN PULMONARY ARTERIES IN PULMONARY ARTERIAL HYPERTENSION
JO  - Artery Research
SP  - 84
EP  - 85
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.119
DO  - 10.1016/j.artres.2017.10.119
ID  - Groeneveldt2017
ER  -