Artery Research

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Volume 20, Issue C, December 2017, Pages 53 - 53

3.2 ASCENDING AND DESCENDING AORTA PULSE WAVE VELOCITY AND DISTENSIBILITY IN BICUSPID AORTIC VALVE PATIENTS

Authors
Andrea Guala1, Jose Rodriguez-Palomares2, Lydia Dux-Santoy2, Gisela Teixido-Tura2, Giuliana Maldonado2, Nicolas Villalva2, Filipa Valente2, Laura Galian2, Marina Huguet1, Laura Gutierrez1, Teresa Gonzalez1, Ruben Fernandez1, Augusto Sao-Aviles1, David Garcia-Dorado1, Artur Evangelista2
1Vall d’Hebron Institute of Research, Vall d’Hebron Hospital, Autonomous University of Barcelona, Spain
2Hospital Universitari Vall d’Hebron, Department of Cardiology, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.032How to use a DOI?
Abstract

Purpose: Bicuspid aortic valve (BAV) is a cardiac congenital disease associated with ascending aorta (AAo) dilation. The study of the impact of aortic biomechanics in this population has been limited by technical difficulties. Contrasting results have been reported for distensibility while studies including regional pulse wave velocity (PWV) are still lacking. Using 4D-flow MRI, we assessed AAo and descending aortic (DAo) biomechanical properties and determined their association in BAV aortopathy.

Methods: One-hundred thirty-six BAV patients with no severe valvular disease and 40 healthy volunteers were recruited. The protocol included a 4D-flow acquisition and a set of 2D CINE PC-MRI at 1.5 T. Aortic 3D geometry was reconstructed from 4D-flow-derived angiography and at least 100 analysis planes were identified in the thoracic aorta. Transit time was calculated on the velocity upslope through wavelet analysis [1]. CINE PC-MRI were used to compute distensibility. Statistical significance is reported corrected for confounding factors.

Results: Non-dilated BAV and controls have similar AAo and DAo PWV and distensibility. Dilated patients presented lower AAo PWV and higher DAo PWV compared to non-dilated (p < 0.001 and p = 0.017, respectively). Distensibility did not differentiate dilated from non-dilated patients and presented lower association with dilation severity (see Figure).

Conclusions: Confirming for the first time previous findings in abdominal aorta aneurysm and fluid-mechanics theory, AAo PWV is reduced in aneurysmatic BAV patients. BAV aortopathy is related to a stiffer DAo. Regional PWV outperforms distensibility as a marker of local aortic biomechanics. These data exclude congenital aortic wall pathology related to BAV

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This is an open access article distributed under the CC BY-NC license.

Reference

1.I Bargiotas et al., Estimation of aortic pulse wave transit time in cardiovascular magnetic resonance using complex wavelet cross-spectrum analysis, J Cardiovasc Magn Reson, Vol. 17, No. 65, 2015, pp. 1-11.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
53 - 53
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.032How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Andrea Guala
AU  - Jose Rodriguez-Palomares
AU  - Lydia Dux-Santoy
AU  - Gisela Teixido-Tura
AU  - Giuliana Maldonado
AU  - Nicolas Villalva
AU  - Filipa Valente
AU  - Laura Galian
AU  - Marina Huguet
AU  - Laura Gutierrez
AU  - Teresa Gonzalez
AU  - Ruben Fernandez
AU  - Augusto Sao-Aviles
AU  - David Garcia-Dorado
AU  - Artur Evangelista
PY  - 2017
DA  - 2017/12/06
TI  - 3.2 ASCENDING AND DESCENDING AORTA PULSE WAVE VELOCITY AND DISTENSIBILITY IN BICUSPID AORTIC VALVE PATIENTS
JO  - Artery Research
SP  - 53
EP  - 53
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.032
DO  - 10.1016/j.artres.2017.10.032
ID  - Guala2017
ER  -