Artery Research

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Volume 20, Issue C, December 2017, Pages 52 - 53

3.1 INTEGRATED CENTRAL PRESSURE-STIFFNESS RISK SCORE: A NEW OPPORTUNITY FOR CARDIOVASCULAR RISK STRATIFICATION. FIRST RESULTS ON CHRONIC KIDNEY DISEASE PATIENTS

Authors
János Nemcsik1, Orsolya Cseprekál2, Ádám Tabák3, Dóra Batta1, József Egresits4, István Kiss5, András Tislér3
1Department of Family Medicine, Semmelweis University, Budapest, Hungary
2Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
31st Department of Medicine, Semmelweis University, Budapest, Hungary
4Department for Internal Medicine and Cardiology, Klinikm Klagenfurt am Wörthersee, Austria
5Division of Nephrology, Department of Medicine, St. Imre Teaching Hospital, Budapest, Hungary
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.031How to use a DOI?
Abstract

Background: The evaluation of arterial stiffness and central haemodynamics represent a new tool of cardiovascular (CV) risk stratification. Our aim was to create an integrated central pressure-stiffness risk score (ICPS score) which incorporate the predictive potential of identical parameters.

Methods: 100 chronic kidney disease patients on conservative therapy (CKD 1–5) were involved in our study. Pulse wave velocity (PWV), augmentation index (Aix), central systolic blood pressure (csys) and central pulse pressure (cPP) were measured.

Patients were followed for 59.7 months and CV morbidity and mortality were registered. Patients were classified into tertiles based on their PWV, Aix, csys and cPP values. After the analysis of the predictive values of the tertiles of the identical parameters, patients were scored. One score was given, when a patient had a third tertile value of PWV, csys or cPP or a second or third tertile value of Aix. Then the CV outcome was analyzed with Cox regression analysis of the groups of patients with different scores.

Results: During follow-up 37 CV events occurred. Compared with the zero-point group (n = 21), the one-point group (n = 25) did not have significantly increased odds ratio (OR) for CV events (OR: 1.10; 95% confidence interval (CI): 0.27–4.44), but the risk has been significantly elevated in the two-point group (n = 29, OR: 4.59, CI: 1.39–15.22) and it increased further in the three-point group (n = 16, OR: 9.03, CI: 2.22–36.65), as well as in the four-point group (n = 9, OR: 11.84, CI: 2.52–55.64).

Conclusion: The ICPS score can help in the identification of chronic kidney disease patients with high CV risk.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
52 - 53
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.031How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - János Nemcsik
AU  - Orsolya Cseprekál
AU  - Ádám Tabák
AU  - Dóra Batta
AU  - József Egresits
AU  - István Kiss
AU  - András Tislér
PY  - 2017
DA  - 2017/12/06
TI  - 3.1 INTEGRATED CENTRAL PRESSURE-STIFFNESS RISK SCORE: A NEW OPPORTUNITY FOR CARDIOVASCULAR RISK STRATIFICATION. FIRST RESULTS ON CHRONIC KIDNEY DISEASE PATIENTS
JO  - Artery Research
SP  - 52
EP  - 53
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.031
DO  - 10.1016/j.artres.2017.10.031
ID  - Nemcsik2017
ER  -