3.3 ASSESSMENT OF AORTIC MORPHOLOGY IN A BICUSPID AORTIC VALVE POPULATION
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- Abstract
Background: Bicuspid aortic valve (BAV) is a congenital heart disease associated with aortic wall abnormalities and co-existing with other congenital defects (e.g. aortic coarctation). This study aimed to explore aortic shape features in a BAV population, identifying sub-groups with different aortic morphologies.
Methods: Single-centre retrospective study. Patients with an MRI scan and native BAV diagnosis between 2011 and 16 were studied (n = 525); those with a 3D MRI dataset were included for shape analysis (n = 108, 64% males, 38 ± 16.5 years). MRI-derived 3D aortic reconstructions were analysed using a statistical shape modelling framework [1]. A mean aortic shape (‘template’) was computed and shape deformations were correlated with demographic, volumetric and functional data.
Results: Aortic coarctation (n = 71) was significantly associated with a more gothic arch (p = 0.02), more tubular ascending aorta and descending aorta dilation (p < 0.001). Also, smaller aortic size in patients with coarctation was associated with the younger age of this group (33 ± 13 vs. 47 ± 19, p < 0.001), given the overall relationship between aortic size and age (p < 0.001). Aortic stenosis (n = 30) was also associated with gothic arch (p = 0.01), and dilated ascending aorta but with no aortic root dilation (p = 0.02).
On multivariate regression analysis, gothic arch was indeed associated with coarctation and stenosis, and also with non-coronary valve fusion pattern (p = 0.03). Patients with aortic regurgitation tended to have larger aortas (p = 0.005).
Conclusion: The presence of aortic coarctation and stenosis may influence the amount of dilation and the overall arch architecture in BAV patients. Patients with BAV present profoundly different morphological phenotypes depending on the presence/absence of aortic coarctation (Fig. 1).
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TY - JOUR AU - Froso Sophocleous AU - Benedetta Biffi AU - Elena Giulia Milano AU - Cha Rajakaruna AU - Massimo Caputo AU - Costanza Emanueli AU - Chiara Bucciarelli-Ducci AU - Tom Gaunt AU - Silvia Schievano AU - Giovanni Biglino PY - 2017 DA - 2017/12/06 TI - 3.3 ASSESSMENT OF AORTIC MORPHOLOGY IN A BICUSPID AORTIC VALVE POPULATION JO - Artery Research SP - 53 EP - 54 VL - 20 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.10.033 DO - 10.1016/j.artres.2017.10.033 ID - Sophocleous2017 ER -