Artery Research

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Volume 24, Issue C, December 2018, Pages 121 - 121

P144 IMPACT OF ANTI-HYPERTENSIVE DRUGS ON AORTIC STIFFNESS INDUCED BY CHRONIC KIDNEY DISEASE AND MINERAL BONE DISORDER IN RATS

Authors
Mohsen Agharazii1, 2, Roth-Visal Ung3, Sarah-Kim Bisson2, Fabrice Mac-Way2, Darren E. Richard2, Richard Larivière2
1CHU de Québec-Université Laval, Québec City, Canada
2Université Laval, Québec City, Canada
3CHU de Québec Research Center, Canada
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.197How to use a DOI?
Abstract

Background: In chronic kidney disease (CKD), anomalies of mineral bone disorder (MBD) play a central role in vascular calcification and increased aortic stiffness. The impact of antihypertensive drugs on MBD-induced vascular calcification remains uncertain. The aim of this study was to examine whether endothelin A receptor antagonist (ETAA), angiotensin type-1 receptor antagonist (AT1A) and the combination of hydralazine/hydrochlorothiazide (HDZ/HCT) can reduce vascular stiffness in a rat model of CKD-MBD.

Method: Using a remnant kidney model of CKD in rats, vascular calcification was induced by creating MBD through high a calcium-phosphate diet and vitamin D supplementation. Three antihypertensive treatments were investigated: atrasentan (ETA blocker), losartan (AT1 blocker) and HDZ/HCT. Blood pressures (BPs) were measured invasively after (6 weeks) and aortic stiffness was determined by the assessment of pulse wave velocity (PWV).

Results: PWV and mean BP increased in rats with CKD-MBD as compared to CKD (640 ± 130 vs. 390 ± 34 cm/s and 100 ± 17 vs. 92 ± 21 mmHg; p p < 0.05). Treatment of CKD-MBD rats with ETAA and AT1A, but not HDZ/HCT, reduced PWV (517 ± 94, 596 ± 134 and 761 ± 116 cm/s respectively) despite similar reduction of mean BP by the different treatments (73 ± 16, 75 ± 19 and 70 ± 20 mmHg, respectively). Creatinine clearance and mineral metabolism parameters were relatively similar among groups.

Conclusion: MBD-induced aortic stiffness in CKD rats was improved by atrasentan and losartan, but not the combination of HDZ/HCT, indicating blood pressure-independent protective effects of ETAA and AT1A.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
121 - 121
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.197How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Mohsen Agharazii
AU  - Roth-Visal Ung
AU  - Sarah-Kim Bisson
AU  - Fabrice Mac-Way
AU  - Darren E. Richard
AU  - Richard Larivière
PY  - 2018
DA  - 2018/12/04
TI  - P144 IMPACT OF ANTI-HYPERTENSIVE DRUGS ON AORTIC STIFFNESS INDUCED BY CHRONIC KIDNEY DISEASE AND MINERAL BONE DISORDER IN RATS
JO  - Artery Research
SP  - 121
EP  - 121
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.197
DO  - 10.1016/j.artres.2018.10.197
ID  - Agharazii2018
ER  -