P143 REDUCED LEVELS OF ANTI-AGEING HORMONE KLOTHO ARE ASSOCIATED WITH INCREASED AORTIC STIFFNESS IN PATIENTS WITH TYPE 2 DIABETES

DOI

10.1016/j.artres.2018.10.196How to use a DOI?

Abstract

Background: Aortic Pulse Wave Velocity (Ao-PWV) predicts cardiovascular disease and renal dysfunction in Type 2 Diabetes (T2DM). Klotho is a circulating anti-ageing hormone that has direct cardio-renal protective effects in animal studies. We have previously demonstrated that circulating levels of Klotho are increased by Renin-angiotensin System inhibition (RASi), inversely associated with albuminuria and predict renal function decline in T2DM. The relationship between Klotho and Ao-PWV in diabetes is unknown.

Methods: We investigated the correlation of serum Klotho levels and Ao-PWV in 92 patients with T2DM (61% male) all on RASi with preserved renal function in a cross-sectional study. Klotho levels were measured using a validated immunoassay and Ao-PWV by applanation tonometry (Sphygmocor system).

Results: The mean age (range) of our cohort was 60.4 (40–82) years with an estimated GFR (using CKD-EPI equation) of 89.2 (46–143) ml/min. Median (interquartile range) Ao-PWV and circulating Klotho levels were 11.8 (10.3–13.6) m/s and 201.46 (154.64–280.17) pg/μl respectively. Patients with an Ao-PWV above the median were older (62.8 ± 9.9 vs 58.1 ± 8.2 years), had a higher SBP (160.9 ± 10.01 vs. 155.04 ± 11.7 mmHg) and lower Klotho levels (192.59 [120.27–255.45] pg/μl vs 219.92 [171.06–311.56] pg/μl), compared to those below the median (p = 0.05 for all).A 10% increase in circulating Klotho levels significantly reduced the odds of a patient being above the Ao-PWV median by 11% in a multivariable logistic regression analysis.

Conclusion: There is an inverse association between Ao-PWV and circulating Klotho levels in T2DM. Treatments and strategies that that increase Klotho may attenuate aortic stiffness in diabetes.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Nikolaos Fountoulakis
AU  - Giuseppe Maltese
AU  - Luigi Gnudi
AU  - Janaka Karalliedde
PY  - 2018
DA  - 2018/12/04
TI  - P143 REDUCED LEVELS OF ANTI-AGEING HORMONE KLOTHO ARE ASSOCIATED WITH INCREASED AORTIC STIFFNESS IN PATIENTS WITH TYPE 2 DIABETES
JO  - Artery Research
SP  - 121
EP  - 121
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.196
DO  - 10.1016/j.artres.2018.10.196
ID  - Fountoulakis2018
ER  -