Artery Research

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Volume 24, Issue C, December 2018, Pages 121 - 122

P145 ARTERIAL STIFFNESS AND LEFT VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH METABOLIC SYNDROME: LONGITUDINAL STUDY

Authors
Svetlana Solovjova1, Ligita Ryliskyte1, 2, Roma Puronaite1, 2, Jelena Celutkiene1, 2, Aleksandras Laucevicius1, 2, Jolita Badariene1, Ieva Slivovskaja1, Egidija Rinkuniene1
1Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania
2Vilnius University, Faculty of Medicine, Vilnius, Lithuania
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.198How to use a DOI?
Abstract

Aim: To evaluate the relation between arterial stiffness and left ventricular diastolic dysfunction (LVDD) in metabolic syndrome (MetS) patients during more than 3 years observation period (average was 3,8 years).

Methods: This longitudinal study enrolled 573 subjects (aged 53,4 ± 6 years, 63% female, 76% hypertensive) from the Lithuanian High Cardiovascular Risk Primary Prevention Programme1, without overt atherosclerotic disease and systolic LV dysfunction. Arterial stiffness parameters (carotid-to-femoral pulse wave velocity(cfPWV), augmentation index (AIxHR75), mean aortic pressure(mAP), central pulse pressure(cPP) were assessed by applanation tonometry. Diastolic function (LVDF) was defined according to the 2016 ESC Guidelines for diagnosis and treatment of acute and chronic heart failure.

Results: In presented cohort most of study subjects had LVDD at first visit (n = 418, n = 325 impaired relaxation, n = 92 pseudonormalisation, n = 1 restrictive LVDD). During the observation LVDF didn’t change in 337 (GR1), deteriorated in 110 (GR2), improved in 126 (GR0) participants. We found significant alterations of arterial and diastolic function parameters(mean): cfPWV 8,55 ± 1,4 vs 8,7 ± 1,6 m/s; AIxHR75 22,8 ± 10,4 vs 24,3 ± 10,8%; mAP 105,3 ± 10,4 vs 101,5±14,8 mmHg; cPP 42,6 ± 9,9 vs 43,3 ± 10,6 mmHg; E/A ratio 1 ± 0,3 vs 0,93 ± 0,2; E/e’mean ratio 10,4 ± 3,5 vs 9,4 ± 2,9; E/e’septal 11,9 ± 4,1 vs 10,9 ± 3,2; MMI 105 ± 22,7 vs 99 ± 24,1 (p < 0,05 for all). Significant correlations were found between initial arterial indices and alterations of LVDF: in GR1 with E/Aratio (rcfPWV = –0.176); in GR0 with E/e’mean (rcfPWV = –0.163, rmAP = –0.171). To clarify the relation between LVDD and arterial stiffness the conditional inference trees analysis was used. Only cfPWV, mAP, heart rate and BMI were significant for presence of LVDD.

Conclusion: Carotid-to-femoral PWV, the biomarker of vascular damage, is significant determinant of LV diastolic dysfunction in MetS patients. Arterial stiffness is a possible causal link to development of LV diastolic dysfunction.

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This is an open access article distributed under the CC BY-NC license.

References

1.A Laucevicius, V Kasiulevicius, D Jatuzis, Z Petrulioniene, L Ryliskyte, E Rinkunien, et al., Lithuanian High cardiovascular Risk (LitHiR) Primary prevention programme – rationale and design, Semin Cardiovasc Med, Vol. 18, 2012, pp. 3.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
121 - 122
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.198How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Svetlana Solovjova
AU  - Ligita Ryliskyte
AU  - Roma Puronaite
AU  - Jelena Celutkiene
AU  - Aleksandras Laucevicius
AU  - Jolita Badariene
AU  - Ieva Slivovskaja
AU  - Egidija Rinkuniene
PY  - 2018
DA  - 2018/12/04
TI  - P145 ARTERIAL STIFFNESS AND LEFT VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH METABOLIC SYNDROME: LONGITUDINAL STUDY
JO  - Artery Research
SP  - 121
EP  - 122
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.198
DO  - 10.1016/j.artres.2018.10.198
ID  - Solovjova2018
ER  -