5.5 MEDIATOR EFFECT OF CARDIORESPIRATORY FITNESS ON THE RELATIONSHIP BETWEEN ARTERIAL STIFFNESS AND COGNITIVE FUNCTION
- DOI
- 10.1016/j.artres.2018.10.052How to use a DOI?
- Abstract
Objective: The study aims to investigate the role of cardiorespiratory fitness as a mediator of the relationship between arterial stiffness and cognitive function in apparently healthy seniors.
Methods: This is a cross-sectional study comprising 155 participants (75.5 ± 6.5 years; 69.7% female). Arterial stiffness and cognitive function were assessed with carotid-femoral pulse wave velocity (cfPWV) (SphygmoCor, AtCor Medical, Australia), and Montreal Cognitive Assessment (MoCA), respectively. Cardiorespiratory fitness was calculated using the 6-minute walk test. Simple mediation analysis with bootstrapped procedures was calculated with Hayes’s PROCESS macro for SPSS.
Results: After adjustments for gender and age, cardiorespiratory fitness significantly mediated the relationship between arterial stiffness and cognitive function (Indirect effect= −0.229 [95% CI, −0.455 to −0.046]).
Conclusion: The present findings suggest that cardiorespiratory fitness, independently of gender and age, is a mediator of the relationship between arterial stiffness and cognitive function.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Download article (PDF)
View full text (HTML)
Cite this article
TY - JOUR AU - Alinne Nascimento AU - Raquel Silva AU - Joana Carvalho AU - Lucimere Bohn PY - 2018 DA - 2018/12/04 TI - 5.5 MEDIATOR EFFECT OF CARDIORESPIRATORY FITNESS ON THE RELATIONSHIP BETWEEN ARTERIAL STIFFNESS AND COGNITIVE FUNCTION JO - Artery Research SP - 79 EP - 79 VL - 24 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2018.10.052 DO - 10.1016/j.artres.2018.10.052 ID - Nascimento2018 ER -