5.5 MEDIATOR EFFECT OF CARDIORESPIRATORY FITNESS ON THE RELATIONSHIP BETWEEN ARTERIAL STIFFNESS AND COGNITIVE FUNCTION

DOI

10.1016/j.artres.2018.10.052How to use a DOI?

Abstract

Objective: The study aims to investigate the role of cardiorespiratory fitness as a mediator of the relationship between arterial stiffness and cognitive function in apparently healthy seniors.

Methods: This is a cross-sectional study comprising 155 participants (75.5 ± 6.5 years; 69.7% female). Arterial stiffness and cognitive function were assessed with carotid-femoral pulse wave velocity (cfPWV) (SphygmoCor, AtCor Medical, Australia), and Montreal Cognitive Assessment (MoCA), respectively. Cardiorespiratory fitness was calculated using the 6-minute walk test. Simple mediation analysis with bootstrapped procedures was calculated with Hayes’s PROCESS macro for SPSS.

Results: After adjustments for gender and age, cardiorespiratory fitness significantly mediated the relationship between arterial stiffness and cognitive function (Indirect effect= −0.229 [95% CI, −0.455 to −0.046]).

Conclusion: The present findings suggest that cardiorespiratory fitness, independently of gender and age, is a mediator of the relationship between arterial stiffness and cognitive function.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Alinne Nascimento
AU  - Raquel Silva
AU  - Joana Carvalho
AU  - Lucimere Bohn
PY  - 2018
DA  - 2018/12/04
TI  - 5.5 MEDIATOR EFFECT OF CARDIORESPIRATORY FITNESS ON THE RELATIONSHIP BETWEEN ARTERIAL STIFFNESS AND COGNITIVE FUNCTION
JO  - Artery Research
SP  - 79
EP  - 79
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.052
DO  - 10.1016/j.artres.2018.10.052
ID  - Nascimento2018
ER  -