Artery Research

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Volume 24, Issue C, December 2018, Pages 79 - 79

5.4 AGE-INDUCED INCREASE IN THE ENERGY TRANSMITTED TOWARDS THE CEREBRAL CIRCULATION AS A CONTRIBUTOR TO IMPAIRED BRAIN FUNCTION

Authors
Stamatia Pagoulatou1, Jonathan Mynard2, 3, Vasiliki Bikia4, Julio Chirinos5, Nikolaos Stergiopulos4, Patrick Segers6
1EPFL, Lausanne, Switzerland
2Murdoch Children’s Research Institute, Parkville, Australia
3University of Melbourne, Parkville, Australia
4EPFL, Lausanne, Switzerland
5University of Pennsylvania Perelman School of Medicine and Hospital of the University of Pennsylvania, Philadelphia, USA
6University of Ghent, Ghent, Belgium
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.051How to use a DOI?
Abstract

Background and Aims: The increase in arterial stiffness and pressure pulsatility with age is identified as a key contributor to cognitive impairment; nevertheless, the underlying hemodynamic mechanisms remain unclear. A hypothesis, proposed by (1), suggests that the preferential stiffening of the central arteries as compared to the periphery changes the impedance distribution of the arterial network and exposes the cerebral circulation to the deleterious effects of excessive pulsatile energy. The aim of the present study was to test this hypothesis using a previously developed mathematical model of the ageing cardiovascular system (2).

Methods: For each decade of age, forward and backward components of wave and hydraulic power and energy were calculated (3) at the ascending aorta as well as at the cerebral blood supply vessels, i.e. the vertebral and internal carotid arteries. Subsequently, we isolated the component of hydraulic energy (HE) related to the initial forward compression wave (FCW) by restricting the analysis to early systole (0–0.2 sec) and calculated the respective energy transmission coefficients.

Results: Ageing was associated with an increase in proximal aortic FCW wave power (dictated by the augmented ventricular contractility) and a slight increase in total hydraulic energy. The FCW energy transmission coefficients were almost doubled for all brain vessels as shown in Fig. 1.

Conclusion: Our findings support the hypothesis that age-related central arterial stiffening leads to an enhanced energy transmission of the early systolic forward wave towards brain vessels, potentially contributing to impaired brain function with increasing age.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
24 - C
Pages
79 - 79
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.051How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Stamatia Pagoulatou
AU  - Jonathan Mynard
AU  - Vasiliki Bikia
AU  - Julio Chirinos
AU  - Nikolaos Stergiopulos
AU  - Patrick Segers
PY  - 2018
DA  - 2018/12/04
TI  - 5.4 AGE-INDUCED INCREASE IN THE ENERGY TRANSMITTED TOWARDS THE CEREBRAL CIRCULATION AS A CONTRIBUTOR TO IMPAIRED BRAIN FUNCTION
JO  - Artery Research
SP  - 79
EP  - 79
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.051
DO  - 10.1016/j.artres.2018.10.051
ID  - Pagoulatou2018
ER  -