P7.02 EFFECT OF CAPTOPRIL AND TELMISARTAN ON ANTI-CONTRACTILE PROPERTY OF PERIVASCULAR ADIPOSE TISSUE LOST AFTER HYPOXIA IN RAT MESENTERIC SMALL RESISTANCE ARTERIES
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- 10.1016/j.artres.2010.10.079How to use a DOI?
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It has been previously demonstrated that inflammation in adipose tissue may be implicated in vascular dysfunction.Adipocytes secrete adiponectin, a physiological modulator of local vascular tone through an increased nitric oxide bioavailability.This capacity is lost in obesity by the development of adipocyte hypertrophy,leading to hypoxia,inflammation, and oxidative stress.
Aim: of the study was to investigate the feasibility a pharmacological modulation of the concerned effect,during hypoxia, in Wistar-Kyoto normotensive rats(WKY).
Materials and Methods: we investigated 25 WKY of 12 weeks of age.Mesenteric small resistance arteries were dissected and mounted on a wire myograph,according to Mulvany-Halpern technique(internal diameter about 200 μm).A concentration-response to norepinephrine(NE,from10−9to10−5Mol/l)was evaluated in the following conditions:1)in vessels with perivascular fat tissue(WF),2)in vessels without perivascular fat tissue(NoF);3)in WF vessels under hypoxic condition(WF+Hyp);4)in NoF vessels under hypoxic condition(NoF+Hyp);5)in WF+Hyp vessels incubated with telmisartan10−2Mol/l (WF+Hyp+Telm)or captopril10−2Mol/l for 3hour(WF+Hyp+Capt).
Results: Are summarized in the figure (active media stress: KPa, mean of two vessels for each rat).A significantly greater reactivity to NE was observed in NoF vessels compared with WF vessels(ANOVAp=0.003between curves).This increased reactivity is similar to that observed in WF+Hyp(ANOVAp= NS between, NoF and WF+Hyp).Captopril and Telmisartan were able to prevent the effect of hypoxia(ANOVA p<0.05 between WF+Hyp and WF+Hyp+Capt or Telm).
In conclusion the ACE inihibitor captopril and the angiotensin-receptor blocker telmisartan seem to be able to restore the anti-contractile effects of perivascular fat tissue lost after hypoxia, possibly through an inihibition of angiotensin II effects.
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TY - JOUR AU - C. Agabiti Rosei AU - A. Greenstein AU - S. Withers AU - A.M. Heagerty PY - 2010 DA - 2010/12/02 TI - P7.02 EFFECT OF CAPTOPRIL AND TELMISARTAN ON ANTI-CONTRACTILE PROPERTY OF PERIVASCULAR ADIPOSE TISSUE LOST AFTER HYPOXIA IN RAT MESENTERIC SMALL RESISTANCE ARTERIES JO - Artery Research SP - 168 EP - 168 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.079 DO - 10.1016/j.artres.2010.10.079 ID - AgabitiRosei2010 ER -