Artery Research

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Volume 4, Issue 4, December 2010, Pages 167 - 168

P7.01 EFFECTS OF OMEGA 3 SUPPLEMENTATION ON ARTERIAL STIFFNESS IN RAT EXPERIMENTAL MENOPAUSE

Authors
P. Losurdo, E. Panizon, M. Jevnikar, L. Macaluso, B. Fabris, B. Toffoli, M. Bardelli, F. Fischetti, G. Biolo, M. Zanetti, S. Mazzucco, G. Gortan Capellari, R. Carretta
Clinical Depart. of Medical, Technological, Translational Sciences of Trieste University, Trieste, Italy
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.078How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aim: To investigate the effects of omega-3 (Ω3) dietary supplementation on large artery mechanics and vascular oxidative stress (VOS), in a rat model of surgical menopause.

Materials and methods: Thirty, 6-months-old, Wistar-Kyoto rats were equally divided into 3 groups: a) control: sham surgery - normal diet (CTRL)-, b) ovariectomy, - normal diet (OVX) -and c) ovariectomy, + Ω3 supplementation (0,8g/Kg/day - daily gavages administration-) (OVX+Ω3). Two months after surgery, carotid-femoral Pulse Wave Velocity (c-f PWV) and arterial pressure were directly measured, by aortic and femoral catheter. VOS was assessed by superoxide anion generation, in aorta rings, (SOD-inhibitable cytochrome C reduction assay). Erythrocytes membrane Ω3 index was measured by gas-chromatography.

Results: The results are shown in the table:

Variable CTRL P-value OVX P-value OVX+Ω3
Final body weight (gr) 211±3,85 0,005 246,4±11,7 < 0,0001vsCTRL 263,3±7,3
c-fPWV cm/sec 378,9±7,2 <,0001 560,8±12,1 < 0,0001 363,3±5,9
MeanBP mmHg 108,8±4,8 0,002 129,8±2,6 0,003 109,3±2,7
Superoxide nmol/min/mm2 97,4±8,3 0,01 142,3±14,6 0,04 105,0±9,8
SystolicBP mmHg 133,1±6,1 0,07 153,3±12,9 0,11 135,9±4,1
DiastolicBP mmHg 96,7±4,6 0,09 109,1±6,9 0,1 97,2±2,6
Ω3 index, percent 3,2±0,1 0,01 2,5±0,08 < 0,0001< 0,0001vsCTRL 5,2±0,2

Conclusions: Ω3 supplementation reduces arterial BP and restores mechanical arterial properties in a post menopause experimental model, likely by restoring NO availability.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
167 - 168
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.078How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - P. Losurdo
AU  - E. Panizon
AU  - M. Jevnikar
AU  - L. Macaluso
AU  - B. Fabris
AU  - B. Toffoli
AU  - M. Bardelli
AU  - F. Fischetti
AU  - G. Biolo
AU  - M. Zanetti
AU  - S. Mazzucco
AU  - G. Gortan Capellari
AU  - R. Carretta
PY  - 2010
DA  - 2010/12/02
TI  - P7.01 EFFECTS OF OMEGA 3 SUPPLEMENTATION ON ARTERIAL STIFFNESS IN RAT EXPERIMENTAL MENOPAUSE
JO  - Artery Research
SP  - 167
EP  - 168
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.078
DO  - 10.1016/j.artres.2010.10.078
ID  - Losurdo2010
ER  -