BLOOD PRESSURE VARIABILITY AND ARTERIAL STIFFNESS

DOI

10.1016/j.artres.2011.10.001How to use a DOI?

Keywords

Arterial stiffness; Blood pressure variability; Wave reflections

Abstract

Blood pressure variability (BPV) is defined by the standard deviation of a given sample of population of normotensive or hypertensive subjects. Recent studies have suggested that this parameter might constitute a cardiovascular risk factor. Reduction of blood pressure variability could be an important purpose of anti-hypertensive treatment, as suggested from experimental studies. In a double-blind controlled investigation, the thiazide compound indapamide was compared to placebo, to the angiotensin blocker candesartan and to the calcium-entry blocker amlodipine for 12 weeks treatment. The 3 drugs reduced significantly and identically blood pressure. Only indapamide and amlodipine reduced significantly BPV. This study was the first to demonstrate the interest of BPV in the setting of a double-blind, placebo controlled, trial.

Copyright

© 2011 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.

Open Access

This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

TY  - JOUR
AU  - Michel E. Safar
PY  - 2011
DA  - 2011/10/28
TI  - BLOOD PRESSURE VARIABILITY AND ARTERIAL STIFFNESS
JO  - Artery Research
SP  - 119
EP  - 121
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.001
DO  - 10.1016/j.artres.2011.10.001
ID  - Safar2011
ER  -